MIR762

Summary

MIR762 (microRNA 762, HGNC:37303) is a microRNA gene on chromosome 16p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313837 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37303
Approved symbol	MIR762
Name	microRNA 762
Location	16p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-762
Ensembl gene	ENSG00000211591
Ensembl biotype	miRNA
Entrez	100313837
RNAcentral	URS000075DA19 — miRNA, 83 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390236

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390236 — 1 exons

Exon	Start	End
ENSE00001507663	30893903	30893985

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 82.04.

Top tissues by expression

2 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
anterior cingulate cortex	UBERON:0009835	82.04	gold quality
stomach	UBERON:0000945	76.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• a complex relationship between tear induction of miR-762, its modulation of innate defense genes, and P. aeruginosa internalization (PMID:23469087)
• Interferon regulatory factor 7 (IRF7) is a direct target of miR-762 and overexpression of miR-762 reduced expression of IRF7. (PMID:26597380)
• Aberrant levels of plasmic miR-144-3p and miR-762 were associated with Grave Disease, which may be biomarkers for Grave disease diagnosis. (PMID:30949910)
• MiR-762 promotes trophoblast cell epithelial-mesenchymal transition (EMT) by targeting directly Grhl2 gene 3’UTR. miR-762 was downregulated in placentas of patients with pre-eclampsia. (PMID:31354028)
• MicroRNA 762 (miR-762) expression is upregulated in gefitinib-resistant non-small-cell lung cancer (NSCLC) tissues and cells, and this upregulation predicts a poor post-chemotherapy prognosis in NSCLC patients. miR-762 upregulation, induced by IL-6 signaling, significantly enhances cell survival and renders NSCLC cells unresponsiveness to gefitinib-elicited cell death. (PMID:31823748)
• Circular RNA FAM114A2 suppresses progression of bladder cancer via regulating NP63 by sponging miR-762. (PMID:31969560)
• Identification of Circulating miR-762 as a Novel Diagnostic and Prognostic Biomarker for Non-Small Cell Lung Cancer. (PMID:33317398)
• Circ_0011460 upregulates HTRA1 expression by sponging miR-762 to suppress HTR8/SVneo cell growth, migration, and invasion. (PMID:34270834)
• A novel miRNA-762/NFIX pathway modulates LPS-induced acute lung injury. (PMID:34492536)
• Exosomes from human induced pluripotent stem cells-derived keratinocytes accelerate burn wound healing through miR-762 mediated promotion of keratinocytes and endothelial cells migration. (PMID:35729564)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.