MIR764

Summary

MIR764 (microRNA 764, HGNC:37306) is a microRNA gene on chromosome Xq23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313838 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37306
Approved symbol	MIR764
Name	microRNA 764
Location	Xq23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-764
Ensembl gene	ENSG00000212100
Ensembl biotype	miRNA
Entrez	100313838
RNAcentral	URS000075B1C9 — miRNA, 85 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390811

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390811 — 1 exons

Exon	Start	End
ENSE00001508488	114639435	114639519

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 70.46.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hypothalamus	UBERON:0001898	70.46	gold quality
urinary bladder	UBERON:0001255	68.36	gold quality
corpus callosum	UBERON:0002336	64.13	gold quality
Ammon’s horn	UBERON:0001954	63.78	gold quality
putamen	UBERON:0001874	63.72	gold quality
nucleus accumbens	UBERON:0001882	61.17	gold quality
caudate nucleus	UBERON:0001873	59.88	gold quality
vagina	UBERON:0000996	58.27	gold quality
right lobe of thyroid gland	UBERON:0001119	56.35	gold quality
right frontal lobe	UBERON:0002810	54.52	gold quality
left testis	UBERON:0004533	47.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• miR-764-5p positively regulates osteoblast differentiation from osteoblast progenitor cells by repressing the translation of CHIP protein (PMID:22407479)
• Circulating miR-15b-5p, miR-338-5p, and miR-764 may be biomarkers for diagnosis of HCC (PMID:26119771)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.