MIR765

Summary

MIR765 (microRNA 765, HGNC:33141) is a microRNA gene on chromosome 1q23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 768220 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33141
Approved symbol	MIR765
Name	microRNA 765
Location	1q23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-765
Ensembl gene	ENSG00000211581
Ensembl biotype	miRNA
Entrez	768220
RNAcentral	URS000068E793 — miRNA, 114 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390226

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390226 — 1 exons

Exon	Start	End
ENSE00001507653	156936131	156936244

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 93.49.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	93.49	gold quality
right uterine tube	UBERON:0001302	92.71	gold quality
sural nerve	UBERON:0015488	87.12	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	84.94	gold quality
prefrontal cortex	UBERON:0000451	84.82	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.80	gold quality
mucosa of transverse colon	UBERON:0004991	82.63	gold quality
endocervix	UBERON:0000458	82.43	gold quality
pituitary gland	UBERON:0000007	81.99	gold quality
prostate gland	UBERON:0002367	81.30	gold quality
right adrenal gland cortex	UBERON:0035827	81.14	gold quality
urinary bladder	UBERON:0001255	81.11	gold quality
fundus of stomach	UBERON:0001160	81.07	gold quality
left uterine tube	UBERON:0001303	80.83	gold quality
right coronary artery	UBERON:0001625	80.55	gold quality
monocyte	CL:0000576	80.30	gold quality
calcaneal tendon	UBERON:0003701	80.21	gold quality
left testis	UBERON:0004533	80.14	gold quality
right lobe of liver	UBERON:0001114	80.10	gold quality
blood	UBERON:0000178	80.07	gold quality
right testis	UBERON:0004534	79.98	gold quality
vagina	UBERON:0000996	79.54	gold quality
ectocervix	UBERON:0012249	79.50	gold quality
adenohypophysis	UBERON:0002196	79.43	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	79.32	gold quality
ascending aorta	UBERON:0001496	79.28	gold quality
myometrium	UBERON:0001296	79.05	gold quality
testis	UBERON:0000473	79.04	gold quality
thoracic aorta	UBERON:0001515	78.92	gold quality
liver	UBERON:0002107	78.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 22)

• Plasma levels of miR-765 and miR-149 might be used as noninvasive biomarkers for the diagnosis of CAD in geriatric people. (PMID:25664324)
• rs3115758 accounts for the susceptibility of arterial stiffening through miR-765-induced apelin repression. (PMID:25882991)
• EMP3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma. (PMID:26398721)
• miR-765 is a potential onco-miR that participates in carcinogenesis of human hepatocellular carcinoma by suppressing INPP4B expression, and might represent a potential therapeutic target for hepatocellular carcinoma patients. (PMID:27062697)
• Our results suggest a general role of miR-206,-381, and 671-5p in SMARCB1 gene silencing of epithelioid sarcomas(ES) , extraskeletal myxoid chondrosarcomas , malignant peripheral nerve sheath tumors and synovial sarcomas . In the future, miR-765 could possibly be a diagnostic tool for ES because of its 97% specificity and 80% sensitivity. (PMID:27223121)
• It regulates tumor development of tongue squamous cell carcinoma together with LINC00511 and LAMC2. (PMID:29315846)
• HOXB9 directly binds to the promoter of microRNA-765 and facilitates its transcription, which in turn targets FOXA2, resulting in a FOXA2 decrease and cancer stem cell increase. Elevated HOXB9 is found in human melanoma tissues, which is associated with microRNA-765 up-regulation and FOXA2 decreases. (PMID:29408459)
• that LINC00994 and RUNX2 are upregulated in pancreatic cancers as compared to non-cancer tissues, while miR-765-3p is downregulated. Silencing of LINC00994 inhibits the growth, migration and invasion, promotes a G1 cell cycle arrest and apoptosis in pancreatic cancer cells in vitro. (PMID:30739523)
• MicroRNA-765 targets MTUS1 to promote the progression of osteosarcoma via mediating ERK/EMT pathway. (PMID:31210288)
• Clinical value of LHPP-associated microRNAs combined with protein induced by vitamin K deficiency or antagonist-II in the diagnosis of alpha-fetoprotein-negative hepatocellular carcinoma. (PMID:31693242)
• MiR-765 functions as a tumour suppressor and eliminates lipids in clear cell renal cell carcinoma by downregulating PLP2. (PMID:31901870)
• miR-765 inhibits the osteogenic differentiation of human bone marrow mesenchymal stem cells by targeting BMP6 via regulating the BMP6/Smad1/5/9 signaling pathway. (PMID:32059748)
• miRNA-765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells. (PMID:32166887)
• Bromodomain-containing protein 4 silencing by microRNA-765 produces anti-ovarian cancer cell activity. (PMID:33686960)
• CD45RO(-)CD8(+) T cell-derived exosomes restrict estrogen-driven endometrial cancer development via the ERbeta/miR-765/PLP2/Notch axis. (PMID:33859750)
• miR-765 targeting PDX1 impairs pancreatic beta-cell function to induce type 2 diabetes. (PMID:34357821)
• Three LHPP gene-targeting co-expressed microRNAs (microRNA-765, microRNA-21, and microRNA-144) promote proliferation, epithelial-mesenchymal transition, invasion, and are independent prognostic biomarkers in renal cell carcinomas patients. (PMID:34699621)
• lncRNA USP30-AS1 sponges miR-765 and modulates the progression of colon cancer. (PMID:35260141)
• TRG16, targeted by miR-765, inhibits breast cancer stem cell-like properties via regulating the NF-kappaB pathway. (PMID:35648115)
• Hsa_circ_0007478 aggravates NLRP3 inflammasome activation and lipid metabolism imbalance in ox-LDL-stimulated macrophage via miR-765/EFNA3 axis. (PMID:36191606)
• Long noncoding RNA long intergenic non-protein-coding RNA 173 contributes to nasopharyngeal carcinoma progression by regulating microRNA-765/Gremlin 1 pathway. (PMID:37365917)
• The role of miR-765 in human cancers. (PMID:39068750)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.