MIR766

Summary

MIR766 (microRNA 766, HGNC:33139) is a microRNA gene on chromosome Xq24.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 768218 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33139
Approved symbol	MIR766
Name	microRNA 766
Location	Xq24
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-766
Ensembl gene	ENSG00000211578
Ensembl biotype	miRNA
OMIM	301062
Entrez	768218
RNAcentral	URS000075ADF2 — miRNA, 111 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390223

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390223 — 1 exons

Exon	Start	End
ENSE00001507650	119646738	119646848

Expression profiles

Bgee: expression breadth broad, 72 present calls, max score 94.09.

Top tissues by expression

72 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	94.09	gold quality
monocyte	CL:0000576	80.04	gold quality
blood	UBERON:0000178	79.89	gold quality
skeletal muscle tissue	UBERON:0001134	79.72	gold quality
fundus of stomach	UBERON:0001160	76.74	gold quality
adrenal tissue	UBERON:0018303	75.56	gold quality
muscle of leg	UBERON:0001383	75.36	gold quality
bone marrow	UBERON:0002371	74.53	gold quality
gastrocnemius	UBERON:0001388	74.21	gold quality
granulocyte	CL:0000094	73.34	gold quality
body of stomach	UBERON:0001161	72.93	gold quality
lymph node	UBERON:0000029	72.78	gold quality
lung	UBERON:0002048	72.04	gold quality
stomach	UBERON:0000945	71.94	gold quality
liver	UBERON:0002107	71.71	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.00	gold quality
left coronary artery	UBERON:0001626	70.47	gold quality
right lobe of liver	UBERON:0001114	70.25	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.88	gold quality
hypothalamus	UBERON:0001898	69.81	gold quality
adrenal gland	UBERON:0002369	69.79	gold quality
multicellular organism	UBERON:0000468	69.65	gold quality
calcaneal tendon	UBERON:0003701	69.53	gold quality
heart	UBERON:0000948	69.50	gold quality
prefrontal cortex	UBERON:0000451	69.36	gold quality
kidney	UBERON:0002113	68.82	gold quality
right atrium auricular region	UBERON:0006631	68.68	gold quality
heart left ventricle	UBERON:0002084	68.24	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.21	gold quality
esophagus mucosa	UBERON:0002469	68.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 23)

• Data indicate that miR-766 regulates SIRT6 expression posttranscriptionally. (PMID:23653361)
• microRNA (miR)-766 binds to the 735G-allele and not the 735A-allele of the hCyp11B2 gene and may downregulate the expression of human aldosterone synthase gene and reduce blood pressure in human subjects containing -344T allele. (PMID:25351194)
• Transduction of miR-339 and miR-766 expressing viruses into colon cancer cell lines (SW480 and HCT116) decreased DNMT3B expression (1.5, 3-fold) and (3, 4-fold), respectively. In addition, DNA methylation of some tumor suppressor genes decreased. (PMID:27668319)
• our study is the first to identify miR-766 as a novel p53 activator that functions by targeting MDM4 and thereby enhancing the p53 signalling axis. (PMID:28430625)
• high level of SF2, as a novel oncoprotein in RCC, was significantly associated with poor survival in a large cohort of RCC specimens. Taken together, our study presents a road map for the prediction and validation of miR-766-3p/SF2 axis and thus imparts a therapeutic way for further RCC progression. (PMID:28657135)
• among differentially expressed miRNAs in SLE patients with renal involvement compared to those without renal involvement, hsa-miR-766-3p, may play pivotal roles in PI3K-AKT-mTOR pathway (PMID:29258102)
• results show that miR-766 affects hepatocellular carcinoma (HCC) progression by modulating NR3C2 expression and is a possible new therapeutic target for patients with HCC (PMID:30130435)
• The miR-766-3p suppressed hepatocellular carcinoma (HCC) cell growth and invasion via a Wnt3a/PRC1 positive regulatory loop, and miR-766-3p may serve as a potential therapeutic target in HCC. (PMID:30145863)
• Study found that circATP8B4 in extracellular vesicles isolated from radioresistant U251 glioma cells acts as a U251 miR766 sponge, which may be involved in glioma radioresistance. (PMID:30664179)
• the expression of inflammatory genes in response to inflammatory stimuli was suppressed in MH7A transduced with miR-766-3p. We showed that miR-766-3p indirectly reduced the activation of NF-kappaB and clarified that this mechanism was partially involved in the reduction of the mineralocorticoid receptor expression (PMID:30769772)
• The circ_0021093/miR-766-3p/MTA3 regulatory axis may be an effective therapeutic target for HCC. (PMID:31330234)
• Knockdown of lncRNA Gm11974 protect against cerebral ischemic reperfusion through miR-766-3p/NR3C2 axis (PMID:31556305)
• The involvement of hsa-miR-766 in regulation of mitochondrial apoptosis pathway. (PMID:32032743)
• Serum exosomal microRNA-766-3p expression is associated with poor prognosis of esophageal squamous cell carcinoma. (PMID:32589328)
• Circ_0088194 Promotes the Invasion and Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the miR-766-3p/MMP2 Axis. (PMID:33692802)
• miR-766-5p Targets Super-Enhancers by Downregulating CBP and BRD4. (PMID:34353856)
• GATA1-induced upregulation of LINC01503 promotes carboplatin resistance in ovarian carcinoma by upregulating PD-L1 via sponging miR-766-5p. (PMID:34425872)
• Circular RNA circFADS2 inhibits the progression of cutaneous squamous cell carcinoma by regulating miR-766-3p/HOXA9 axis. (PMID:34913472)
• The lncRNA H19/miR-766-3p/S1PR3 Axis Contributes to the Hyperproliferation of Keratinocytes and Skin Inflammation in Psoriasis via the AKT/mTOR Pathway. (PMID:34992498)
• MiR-766-3p Suppresses Malignant Behaviors and Stimulates Apoptosis of Colon Cancer Cells via Targeting TGFBI. (PMID:35083181)
• Circular RNA CircSHKBP1 accelerates the proliferation, invasion, angiogenesis, and stem cell-like properties via modulation of microR-766-5p/high mobility group AT-hook 2 axis in laryngeal squamous cell carcinoma. (PMID:35502885)
• Circ_0000479 promotes proliferation, invasion, migration and inflammation and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes via miR-766/FKBP5 axis. (PMID:36941600)
• MiR-766-3p and miR-671-5p attenuate aristolochic acid-induced hepatotoxicity by directly targeting the key bioactivating enzyme NQO1. (PMID:37285672)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.