MIR767

Summary

MIR767 (microRNA 767, HGNC:33136) is a microRNA gene on chromosome Xq28.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 768215 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33136
Approved symbol	MIR767
Name	microRNA 767
Location	Xq28
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-767
Ensembl gene	ENSG00000211583
Ensembl biotype	miRNA
Entrez	768215
RNAcentral	URS000075ED21 — miRNA, 109 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390228

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390228 — 1 exons

Exon	Start	End
ENSE00001507655	152393421	152393529

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 77.76.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	77.76	gold quality
stomach	UBERON:0000945	74.22	gold quality
blood	UBERON:0000178	71.28	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.78	gold quality
tibial nerve	UBERON:0001323	66.83	gold quality
esophagus mucosa	UBERON:0002469	65.57	gold quality
transverse colon	UBERON:0001157	65.05	gold quality
corpus callosum	UBERON:0002336	63.67	gold quality
right frontal lobe	UBERON:0002810	51.71	gold quality
anterior cingulate cortex	UBERON:0009835	50.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• GABRA3 also carries a microRNA (miR-767) with predicted target sites in TET1 and TET3, two members of the ten-eleven-translocation family of tumor suppressor genes, involved in the conversion of 5-methylcytosines to 5-hydroxymethylcytosines in DNA. (PMID:25089631)
• MiR-767 acted as a role of tumor promoter by targeting CYLD in human melanoma. (PMID:29054757)
• In this study, we found downregulation of miR-767-3p and upregulation of CLDN18 in lung adenocarcinoma tissue and cell lines. (PMID:29169410)
• hsa_circ_0000673 promoted hepatocellular carcinoma malignant behaviors via regulating miR-767-3p/SET pathway. (PMID:29627570)
• study revealed that miR7675p levels were significantly reduced in glioma tissues and cell lines. Its ectopic expression significantly inhibited cell growth, migration, and invasion, and induced cell cycle arrest and apoptosis. miR7675p negatively regulates the expression of SUZ12 by binding to the SUZ12 3’UTR in glioma cells, leading to downregulation of SUZ12 protein. (PMID:31115583)
• Functional analysis of miR-767-5p during the progression of hepatocellular carcinoma and the clinical relevance of its dysregulation. (PMID:32333091)
• Hsa_circ_0018818 knockdown suppresses tumorigenesis in non-small cell lung cancer by sponging miR-767-3p. (PMID:32357143)
• Identification and Expression of Several Circular RNAs and Knockdown of hsa_circ_0005556 Exerts Oncogenic Functions by miR-767-5p in Gastric Cancer. (PMID:32728015)
• Long noncoding RNA RP11-909N17.2 promotes proliferation, invasion, and migration of hepatocellular carcinoma by regulating microRNA-767-3p. (PMID:33210543)
• Hsa_circ_0052611 and mir-767-5p guide the warburg effect, migration, and invasion of BRCA cells through modulating SCAI. (PMID:37743442)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.