MIR769

Summary

MIR769 (microRNA 769, HGNC:33138) is a microRNA gene on chromosome 19q13.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 768217 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33138
Approved symbol	MIR769
Name	microRNA 769
Location	19q13.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-769
Ensembl gene	ENSG00000211580
Ensembl biotype	miRNA
Entrez	768217
RNAcentral	URS000075D819 — miRNA, 118 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390225

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390225 — 1 exons

Exon	Start	End
ENSE00001507652	46018932	46019049

Expression profiles

Bgee: expression breadth broad, 76 present calls, max score 78.53.

Top tissues by expression

76 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	78.53	gold quality
blood	UBERON:0000178	78.15	gold quality
muscle of leg	UBERON:0001383	77.24	gold quality
gastrocnemius	UBERON:0001388	74.39	gold quality
adenohypophysis	UBERON:0002196	74.14	gold quality
bone marrow	UBERON:0002371	72.59	gold quality
heart left ventricle	UBERON:0002084	70.92	gold quality
left coronary artery	UBERON:0001626	70.73	gold quality
adult mammalian kidney	UBERON:0000082	70.63	gold quality
smooth muscle tissue	UBERON:0001135	69.63	gold quality
urinary bladder	UBERON:0001255	69.54	gold quality
right atrium auricular region	UBERON:0006631	69.33	gold quality
body of uterus	UBERON:0009853	69.25	gold quality
tibial artery	UBERON:0007610	69.22	gold quality
body of stomach	UBERON:0001161	69.10	gold quality
islet of Langerhans	UBERON:0000006	69.06	gold quality
stomach	UBERON:0000945	68.56	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.49	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.49	gold quality
right adrenal gland cortex	UBERON:0035827	68.20	gold quality
right hemisphere of cerebellum	UBERON:0014890	68.16	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.76	gold quality
body of pancreas	UBERON:0001150	67.69	gold quality
fundus of stomach	UBERON:0001160	67.67	gold quality
cerebellar hemisphere	UBERON:0002245	67.61	gold quality
placenta	UBERON:0001987	67.50	gold quality
esophagus	UBERON:0001043	67.35	gold quality
minor salivary gland	UBERON:0001830	67.20	gold quality
ascending aorta	UBERON:0001496	67.02	gold quality
lung	UBERON:0002048	67.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 17)

• miR-769-3p can functionally regulate NDRG1 during changes in oxygen concentration. (PMID:25081069)
• miR-769 might act as a tumor promoter by targeting GSK3B during development of human melanoma. (PMID:27470346)
• identified miR-769-5p, miR-320a and miR-22-3p as potential blood-based biomarkers for TB. In addition, miR-320a may represent a biomarker for drug-resistant TB. (PMID:28910318)
• Epidermal growth factor receptor (EGFR) is identified as a direct target gene of miR-769-5p. (PMID:30601026)
• the up-regulated expression of miR-769-5p contributed to Hepatocellular carcinoma progression possibly by targeting RYBP. (PMID:31545279)
• MiR-769-5p inhibits cancer progression in oral squamous cell carcinoma by directly targeting JAK1/STAT3 pathway. (PMID:32064884)
• A Novel Three-miRNA Signature Identified Using Bioinformatics Predicts Survival in Esophageal Carcinoma. (PMID:32104700)
• MiR-769-5p functions as an oncogene by down-regulating RYBP expression in gastric cancer. (PMID:32633360)
• Long non-coding RNA RP11-284F21.9 functions as a ceRNA regulating PPWD1 by competitively binding to miR-769-3p in cervical carcinoma. (PMID:32936290)
• Long non-coding RNA HAND2-AS1 inhibits gastric cancer progression by suppressing TCEAL7 expression via targeting miR-769-5p. (PMID:32952069)
• LncRNA H19 promotes keloid formation through targeting the miR-769-5p/EIF3A pathway. (PMID:33389493)
• The novel circular RNA circ-PGAP3 retards cervical cancer growth by regulating the miR-769-5p/p53 axis. (PMID:33591461)
• Knockdown of MALAT1 Inhibits the Progression of Chronic Periodontitis via Targeting miR-769-5p/HIF3A Axis. (PMID:33604388)
• Involvement of miR-769-5p/Retinoic Acid Receptor Responder 1 Axis in the Progression of Osteosarcoma: Characterization of Potential Therapeutic Targets. (PMID:35152215)
• Exosome-transmitted miR-769-5p confers cisplatin resistance and progression in gastric cancer by targeting CASP9 and promoting the ubiquitination degradation of p53. (PMID:35522909)
• Circ_0084188 Regulates the progression of colorectal cancer through the miR-769-5p/KIF20A axis. (PMID:36763221)
• CircRNA LOC729852 promotes bladder cancer progression by regulating macrophage polarization and recruitment via the miR-769-5p/IL-10 axis. (PMID:38506082)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.