MIR770

Summary

MIR770 (microRNA 770, HGNC:33143) is a microRNA gene on chromosome 14q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 768222 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33143
Approved symbol	MIR770
Name	microRNA 770
Location	14q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-770
Ensembl gene	ENSG00000211574
Ensembl biotype	miRNA
Entrez	768222
RNAcentral	URS000075BA84 — miRNA, 98 nt, 16 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390219

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390219 — 1 exons

Exon	Start	End
ENSE00001507646	100852390	100852487

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 95.92.

Top tissues by expression

36 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
anterior cingulate cortex	UBERON:0009835	95.92	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	86.50	gold quality
gastrocnemius	UBERON:0001388	71.40	gold quality
blood	UBERON:0000178	70.96	gold quality
heart left ventricle	UBERON:0002084	69.49	gold quality
right atrium auricular region	UBERON:0006631	69.12	gold quality
right lobe of liver	UBERON:0001114	68.47	gold quality
left lobe of thyroid gland	UBERON:0001120	67.47	gold quality
thoracic aorta	UBERON:0001515	65.07	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.06	gold quality
right lobe of thyroid gland	UBERON:0001119	65.03	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.96	gold quality
skin of abdomen	UBERON:0001416	63.11	gold quality
thyroid gland	UBERON:0002046	62.95	gold quality
tibial artery	UBERON:0007610	62.94	gold quality
esophagus mucosa	UBERON:0002469	62.82	gold quality
body of stomach	UBERON:0001161	62.28	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.12	gold quality
ascending aorta	UBERON:0001496	62.00	gold quality
minor salivary gland	UBERON:0001830	61.90	gold quality
vagina	UBERON:0000996	61.75	gold quality
body of pancreas	UBERON:0001150	61.01	gold quality
skin of leg	UBERON:0001511	60.82	gold quality
transverse colon	UBERON:0001157	60.58	gold quality
subcutaneous adipose tissue	UBERON:0002190	60.52	gold quality
upper lobe of left lung	UBERON:0008952	59.55	gold quality
muscle layer of sigmoid colon	UBERON:0035805	58.07	gold quality
omental fat pad	UBERON:0010414	57.56	gold quality
tibial nerve	UBERON:0001323	56.40	gold quality
urinary bladder	UBERON:0001255	53.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• overexpression of PCGEM1 in synoviocytes suppressed miR-770 by direct binding (PMID:26340084)
• microRNA-770 was identified as an important downstream target of Wnt/beta-catenin signaling, to inhibit FBXW7 expression through targeting its 3’-untranslated region. Thus, our results suggest a previously unknown Wnt/beta catenin-miR-770-FBXW7 molecular network in the HCC development. (PMID:26602384)
• Five miRNAs were significantly upregulated in type 2 diabetes mellitus patients (p < 0.05) including miR-661, miR-571, miR-770-5p, miR-892b and miR-1303. Moreover, the levels of the five miRNAs were higher in patients with complications than in those without complications. (PMID:26831044)
• Results indicate that ERCC excision repair 2 (ERCC2) is a potential target of miR-770-5p. (PMID:27449101)
• MiR-770-5p and PBK levels were inversely correlated in xenograft model mice. (PMID:28333152)
• MEG3 and miR-770 was significantly downregulated in gastric cardia adenocarcinoma patients and cell lines, and their expression was associated with TNM stage and lymph node metastasis. Overexpression of MEG3 and miR-770 inhibited gastric cancer cell proliferation and invasion in vitro. (PMID:28345805)
• study indicates that miR-770 functions as a tumor suppressor and it might be a potential biomarker and therapeutic target in non-small cell lung cancer. (PMID:28882645)
• The miR-770 could suppress the doxorubicin-resistance and metastasis of triple negative breast cancer cells, which broaden our insights into the underlying mechanisms in chemo-resistance and metastasis and the tumor suppression effect of miR-770 was mediated by targeting of STMN1. (PMID:29323124)
• Circulating mir-770-5p was negatively correlated with HbA1c in Type 1 diabetics. (PMID:29453204)
• Overexpression of miR-770 indicates a favorable prognosis and suppresses tumorigenesis by modulating PI3K-AKT pathway in glioma. (PMID:31002138)
• miR-770-5p regulates cancer cell proliferation by targeting several genes involved in the HER2 signaling pathway. (PMID:31009516)
• Long noncoding RNA TPT1-AS1 downregulates the microRNA-770-5p expression to inhibit glioma cell autophagy and promote proliferation through STMN1 upregulation. (PMID:31637705)
• Dysregulation of microRNA-770-5p influences pancreatic-beta-cell function by targeting TP53 regulated inhibitor of apoptosis 1 in gestational diabetes mellitus. (PMID:32016984)
• MiR-770-5p facilitates podocyte apoptosis and inflammation in diabetic nephropathy by targeting TIMP3. (PMID:32309847)
• MiR-770 promotes oral squamous cell carcinoma migration and invasion by regulating the Sirt7/Smad4 pathway. (PMID:33326690)
• miR-770-5p regulates EMT and invasion in TNBC cells by targeting DNMT3A. (PMID:33798630)
• CircABCC3 knockdown inhibits glioblastoma cell malignancy by regulating miR-770-5p/SOX2 axis through PI3K/AKT signaling pathway. (PMID:33811842)
• MiR-770-5p, miR-661 and miR-571 expression level in serum and tissue samples of foot ulcer caused by diabetes mellitus type II in Iranian population. (PMID:34643918)
• The important role of miR-770 as a novel potential diagnostic and therapeutic target for human cancer and other diseases. (PMID:37267769)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir770	ENSMUSG00000076451
rattus_norvegicus	Mir770	ENSRNOG00000040384

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.