MIR7703

Summary

MIR7703 (microRNA 7703, HGNC:50271) is a microRNA gene on chromosome 14q12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465801 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50271
Approved symbol	MIR7703
Name	microRNA 7703
Location	14q12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7703
Ensembl gene	ENSG00000283856
Ensembl biotype	miRNA
Entrez	102465801
RNAcentral	URS000075D920 — ncRNA, 77 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620784

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620784 — 1 exons

Exon	Start	End
ENSE00003726220	24143489	24143565

Expression profiles

Bgee: expression breadth broad, 25 present calls, max score 67.69.

Top tissues by expression

25 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of stomach	UBERON:0001161	67.69	gold quality
heart left ventricle	UBERON:0002084	67.38	gold quality
putamen	UBERON:0001874	66.64	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.87	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.40	gold quality
anterior cingulate cortex	UBERON:0009835	63.55	gold quality
hypothalamus	UBERON:0001898	63.10	gold quality
gall bladder	UBERON:0002110	62.97	gold quality
esophagus mucosa	UBERON:0002469	60.28	gold quality
vagina	UBERON:0000996	60.23	gold quality
omental fat pad	UBERON:0010414	60.06	gold quality
left coronary artery	UBERON:0001626	59.89	gold quality
minor salivary gland	UBERON:0001830	59.56	gold quality
right frontal lobe	UBERON:0002810	58.53	gold quality
transverse colon	UBERON:0001157	57.90	gold quality
upper lobe of left lung	UBERON:0008952	56.24	gold quality
blood	UBERON:0000178	54.58	gold quality
thoracic mammary gland	UBERON:0005200	52.50	gold quality
substantia nigra	UBERON:0002038	50.49	gold quality
amygdala	UBERON:0001876	50.13	gold quality
right lobe of thyroid gland	UBERON:0001119	48.36	gold quality
body of pancreas	UBERON:0001150	47.68	gold quality
skin of leg	UBERON:0001511	47.29	gold quality
tibial nerve	UBERON:0001323	44.92	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	36.41	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.