MIR7704

Summary

MIR7704 (microRNA 7704, HGNC:50089) is a microRNA gene on chromosome 2q31.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465802 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50089
Approved symbol	MIR7704
Name	microRNA 7704
Location	2q31.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7704
Ensembl gene	ENSG00000283880
Ensembl biotype	miRNA
Entrez	102465802
RNAcentral	URS00007E412B — ncRNA, 59 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000610524

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000610524 — 1 exons

Exon	Start	End
ENSE00003747725	176188843	176188901

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 77.91.

Top tissues by expression

7 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lung	UBERON:0002048	77.91	gold quality
left adrenal gland cortex	UBERON:0035825	65.50	gold quality
esophagus mucosa	UBERON:0002469	63.94	gold quality
omental fat pad	UBERON:0010414	62.34	gold quality
right frontal lobe	UBERON:0002810	61.97	gold quality
subcutaneous adipose tissue	UBERON:0002190	59.53	gold quality
adrenal gland	UBERON:0002369	52.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Spliceosome-Associated microRNAs Signify Breast Cancer Cells and Portray Potential Novel Nuclear Targets. (PMID:33143250)
• Faecal hsa-miR-7704 inhibits the growth and adhesion of Bifidobacterium longum by suppressing ProB and aggravates hepatic encephalopathy. (PMID:38396001)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.