MIR7706

Summary

MIR7706 (microRNA 7706, HGNC:50110) is a microRNA gene on chromosome 15q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465803 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50110
Approved symbol	MIR7706
Name	microRNA 7706
Location	15q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7706
Ensembl gene	ENSG00000284160
Ensembl biotype	miRNA
Entrez	102465803
RNAcentral	URS00007E3BAE — miRNA, 67 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613747

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613747 — 1 exons

Exon	Start	End
ENSE00003714254	85380596	85380662

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 74.01.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 16.2159 / max 207.4835, expressed in 1744 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
148173	16.2159	1744

Top tissues by expression

6 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
dorsolateral prefrontal cortex	UBERON:0009834	74.01	gold quality
lung	UBERON:0002048	65.42	gold quality
vagina	UBERON:0000996	63.17	gold quality
ascending aorta	UBERON:0001496	62.81	gold quality
putamen	UBERON:0001874	62.00	gold quality
omental fat pad	UBERON:0010414	50.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The investigation of circRNA profiling reveals the regulatory role of the hsa_circ_0000375/miR-7706 pathway in breast cancer. (PMID:37904009)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.