MIR7845

Summary

MIR7845 (microRNA 7845, HGNC:50267) is a microRNA gene on chromosome 2q33.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465835 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50267
Approved symbol	MIR7845
Name	microRNA 7845
Location	2q33.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7845
Ensembl gene	ENSG00000277590
Ensembl biotype	miRNA
Entrez	102465835
RNAcentral	URS000075BD6E — miRNA, 99 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618396

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618396 — 1 exons

Exon	Start	End
ENSE00003730606	207166400	207166498

Expression profiles

Bgee: expression breadth broad, 88 present calls, max score 96.44.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.4516 / max 402.6642, expressed in 1545 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
24854	7.0372	1521
24853	0.4144	172

Top tissues by expression

88 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	96.44	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	86.11	gold quality
sural nerve	UBERON:0015488	85.05	gold quality
monocyte	CL:0000576	84.85	gold quality
blood	UBERON:0000178	78.75	gold quality
calcaneal tendon	UBERON:0003701	78.69	gold quality
bone marrow	UBERON:0002371	77.59	gold quality
gastrocnemius	UBERON:0001388	74.82	gold quality
placenta	UBERON:0001987	73.93	gold quality
stomach	UBERON:0000945	72.21	gold quality
right adrenal gland cortex	UBERON:0035827	72.14	gold quality
right atrium auricular region	UBERON:0006631	71.82	gold quality
heart	UBERON:0000948	71.52	gold quality
adrenal tissue	UBERON:0018303	71.51	gold quality
right adrenal gland	UBERON:0001233	71.36	gold quality
myometrium	UBERON:0001296	71.23	gold quality
prefrontal cortex	UBERON:0000451	71.06	gold quality
body of stomach	UBERON:0001161	71.05	gold quality
heart left ventricle	UBERON:0002084	70.98	gold quality
substantia nigra	UBERON:0002038	70.91	gold quality
tibial artery	UBERON:0007610	70.90	gold quality
liver	UBERON:0002107	70.83	gold quality
popliteal artery	UBERON:0002250	70.82	gold quality
urinary bladder	UBERON:0001255	70.79	gold quality
left adrenal gland	UBERON:0001234	70.70	gold quality
ascending aorta	UBERON:0001496	70.66	gold quality
body of pancreas	UBERON:0001150	70.45	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.31	gold quality
thoracic aorta	UBERON:0001515	70.30	gold quality
left coronary artery	UBERON:0001626	70.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.