MIR7848

Summary

MIR7848 (microRNA 7848, HGNC:50058) is a microRNA gene on chromosome 8q24.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466865 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50058
Approved symbol	MIR7848
Name	microRNA 7848
Location	8q24.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7848
Ensembl gene	ENSG00000276961
Ensembl biotype	miRNA
Entrez	102466865
RNAcentral	URS000075EC0C — ncRNA, 101 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617402

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617402 — 1 exons

Exon	Start	End
ENSE00003716438	133046481	133046581

Expression profiles

Bgee: expression breadth broad, 99 present calls, max score 92.30.

Top tissues by expression

99 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	92.30	gold quality
monocyte	CL:0000576	88.68	gold quality
bone marrow	UBERON:0002371	87.64	gold quality
granulocyte	CL:0000094	84.24	gold quality
left lobe of thyroid gland	UBERON:0001120	83.87	gold quality
vermiform appendix	UBERON:0001154	83.40	gold quality
right lobe of thyroid gland	UBERON:0001119	83.27	gold quality
tonsil	UBERON:0002372	82.34	gold quality
thyroid gland	UBERON:0002046	82.12	gold quality
skeletal muscle tissue	UBERON:0001134	81.56	gold quality
spleen	UBERON:0002106	81.04	gold quality
right lung	UBERON:0002167	79.26	gold quality
upper lobe of left lung	UBERON:0008952	78.89	gold quality
lung	UBERON:0002048	78.33	gold quality
small intestine Peyer’s patch	UBERON:0003454	77.41	gold quality
small intestine	UBERON:0002108	77.39	gold quality
left uterine tube	UBERON:0001303	76.62	gold quality
adenohypophysis	UBERON:0002196	75.73	gold quality
right ovary	UBERON:0002118	75.72	gold quality
lymph node	UBERON:0000029	75.33	gold quality
multicellular organism	UBERON:0000468	75.09	gold quality
liver	UBERON:0002107	74.80	gold quality
muscle of leg	UBERON:0001383	74.65	gold quality
gastrocnemius	UBERON:0001388	74.45	gold quality
placenta	UBERON:0001987	74.08	gold quality
urinary bladder	UBERON:0001255	73.81	gold quality
descending thoracic aorta	UBERON:0002345	73.80	gold quality
endocervix	UBERON:0000458	73.50	gold quality
intestine	UBERON:0000160	73.18	gold quality
omental fat pad	UBERON:0010414	72.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.18

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.