MIR7849

Summary

MIR7849 (microRNA 7849, HGNC:50166) is a microRNA gene on chromosome 4q31.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465837 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50166
Approved symbol	MIR7849
Name	microRNA 7849
Location	4q31.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7849
Ensembl gene	ENSG00000278438
Ensembl biotype	miRNA
Entrez	102465837
RNAcentral	URS000075B5B3 — miRNA, 106 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619235

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619235 — 1 exons

Exon	Start	End
ENSE00003743711	146408583	146408688

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 78.60.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	78.60	gold quality
adrenal tissue	UBERON:0018303	78.39	gold quality
stomach	UBERON:0000945	76.06	gold quality
blood	UBERON:0000178	75.66	gold quality
islet of Langerhans	UBERON:0000006	74.84	gold quality
endometrium	UBERON:0001295	73.46	gold quality
tibial artery	UBERON:0007610	73.16	gold quality
liver	UBERON:0002107	72.60	gold quality
bone marrow	UBERON:0002371	72.28	gold quality
body of stomach	UBERON:0001161	71.68	gold quality
heart	UBERON:0000948	70.23	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.07	gold quality
left adrenal gland	UBERON:0001234	69.67	gold quality
thoracic aorta	UBERON:0001515	69.63	gold quality
intestine	UBERON:0000160	69.08	gold quality
ascending aorta	UBERON:0001496	68.98	gold quality
lung	UBERON:0002048	68.88	gold quality
body of pancreas	UBERON:0001150	68.58	gold quality
thoracic mammary gland	UBERON:0005200	68.49	gold quality
transverse colon	UBERON:0001157	68.24	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.05	gold quality
colon	UBERON:0001155	67.86	gold quality
heart left ventricle	UBERON:0002084	67.72	gold quality
right atrium auricular region	UBERON:0006631	67.62	gold quality
vagina	UBERON:0000996	67.60	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.50	gold quality
esophagus mucosa	UBERON:0002469	67.49	gold quality
minor salivary gland	UBERON:0001830	67.43	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.38	gold quality
left ovary	UBERON:0002119	67.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.