MIR7850

Summary

MIR7850 (microRNA 7850, HGNC:50118) is a microRNA gene on chromosome 19p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465838 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50118
Approved symbol	MIR7850
Name	microRNA 7850
Location	19p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7850
Ensembl gene	ENSG00000277904
Ensembl biotype	miRNA
Entrez	102465838
RNAcentral	URS000075AA54 — ncRNA, 79 nt, 9 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618087

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618087 — 1 exons

Exon	Start	End
ENSE00003746684	2630715	2630793

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 80.16.

Top tissues by expression

56 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	80.16	gold quality
monocyte	CL:0000576	79.10	gold quality
blood	UBERON:0000178	75.41	gold quality
body of stomach	UBERON:0001161	70.68	gold quality
heart left ventricle	UBERON:0002084	69.17	gold quality
body of pancreas	UBERON:0001150	68.46	gold quality
Ammon’s horn	UBERON:0001954	68.06	gold quality
liver	UBERON:0002107	67.10	gold quality
right lobe of liver	UBERON:0001114	66.82	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.81	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.77	gold quality
adult mammalian kidney	UBERON:0000082	66.58	gold quality
left coronary artery	UBERON:0001626	66.52	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.22	gold quality
lung	UBERON:0002048	65.20	gold quality
thoracic mammary gland	UBERON:0005200	64.73	gold quality
putamen	UBERON:0001874	64.61	gold quality
right atrium auricular region	UBERON:0006631	64.43	gold quality
caudate nucleus	UBERON:0001873	64.38	gold quality
right frontal lobe	UBERON:0002810	64.22	gold quality
hypothalamus	UBERON:0001898	64.20	gold quality
upper lobe of left lung	UBERON:0008952	64.11	gold quality
myometrium	UBERON:0001296	64.10	gold quality
transverse colon	UBERON:0001157	64.06	gold quality
substantia nigra	UBERON:0002038	64.06	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.74	gold quality
esophagus mucosa	UBERON:0002469	63.50	gold quality
skin of abdomen	UBERON:0001416	63.40	gold quality
body of uterus	UBERON:0009853	63.04	gold quality
ascending aorta	UBERON:0001496	63.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.