MIR7851

Summary

MIR7851 (microRNA 7851, HGNC:50127) is a microRNA gene on chromosome 12q12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102467003 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50127
Approved symbol	MIR7851
Name	microRNA 7851
Location	12q12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7851
Ensembl gene	ENSG00000278520
Ensembl biotype	miRNA
Entrez	102467003
RNAcentral	URS000075A7B6 — miRNA, 160 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000610611

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000610611 — 1 exons

Exon	Start	End
ENSE00003753381	42323700	42323859

Expression profiles

Bgee: expression breadth broad, 100 present calls, max score 80.88.

Top tissues by expression

100 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	80.88	gold quality
blood	UBERON:0000178	78.14	gold quality
lymph node	UBERON:0000029	75.34	gold quality
spleen	UBERON:0002106	74.39	gold quality
duodenum	UBERON:0002114	74.15	gold quality
tonsil	UBERON:0002372	73.64	gold quality
leukocyte	CL:0000738	72.28	gold quality
prefrontal cortex	UBERON:0000451	71.98	gold quality
bone marrow	UBERON:0002371	71.49	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.99	gold quality
vermiform appendix	UBERON:0001154	70.77	gold quality
monocyte	CL:0000576	70.28	gold quality
corpus callosum	UBERON:0002336	67.88	gold quality
islet of Langerhans	UBERON:0000006	67.16	gold quality
right coronary artery	UBERON:0001625	66.36	gold quality
gastrocnemius	UBERON:0001388	65.93	gold quality
muscle of leg	UBERON:0001383	65.63	gold quality
small intestine	UBERON:0002108	64.68	gold quality
fundus of stomach	UBERON:0001160	64.54	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.50	gold quality
adult mammalian kidney	UBERON:0000082	64.19	gold quality
fallopian tube	UBERON:0003889	63.95	gold quality
upper lobe of left lung	UBERON:0008952	62.79	gold quality
gall bladder	UBERON:0002110	62.36	gold quality
lower esophagus mucosa	UBERON:0035834	62.20	gold quality
body of stomach	UBERON:0001161	62.02	gold quality
liver	UBERON:0002107	61.82	gold quality
stomach	UBERON:0000945	61.56	gold quality
body of pancreas	UBERON:0001150	61.53	gold quality
lung	UBERON:0002048	61.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.