MIR7853

Summary

MIR7853 (microRNA 7853, HGNC:49933) is a microRNA gene on chromosome 6p25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466866 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49933
Approved symbol	MIR7853
Name	microRNA 7853
Location	6p25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7853
Ensembl gene	ENSG00000263572
Ensembl biotype	miRNA
Entrez	102466866
RNAcentral	URS000075EAD0 — ncRNA, 132 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584820

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584820 — 1 exons

Exon	Start	End
ENSE00002694470	6169304	6169435

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 78.86.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	78.86	gold quality
adult mammalian kidney	UBERON:0000082	77.18	gold quality
liver	UBERON:0002107	76.46	gold quality
right adrenal gland cortex	UBERON:0035827	73.40	gold quality
urinary bladder	UBERON:0001255	73.14	gold quality
mucosa of stomach	UBERON:0001199	72.32	gold quality
stomach	UBERON:0000945	72.16	gold quality
vermiform appendix	UBERON:0001154	71.97	gold quality
bone marrow	UBERON:0002371	71.86	gold quality
blood	UBERON:0000178	71.22	gold quality
islet of Langerhans	UBERON:0000006	71.15	gold quality
left adrenal gland cortex	UBERON:0035825	70.84	gold quality
prostate gland	UBERON:0002367	69.62	gold quality
gastrocnemius	UBERON:0001388	69.31	gold quality
body of pancreas	UBERON:0001150	69.14	gold quality
calcaneal tendon	UBERON:0003701	69.03	gold quality
placenta	UBERON:0001987	69.00	gold quality
descending thoracic aorta	UBERON:0002345	68.98	gold quality
kidney	UBERON:0002113	68.47	gold quality
thoracic aorta	UBERON:0001515	68.15	gold quality
right adrenal gland	UBERON:0001233	68.12	gold quality
heart	UBERON:0000948	67.64	gold quality
left coronary artery	UBERON:0001626	67.54	gold quality
ascending aorta	UBERON:0001496	67.30	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.10	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.00	gold quality
lower esophagus	UBERON:0013473	66.95	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.89	gold quality
body of stomach	UBERON:0001161	66.81	gold quality
adipose tissue	UBERON:0001013	66.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.