MIR7854

Summary

MIR7854 (microRNA 7854, HGNC:50047) is a microRNA gene on chromosome 16q23.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465840 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50047
Approved symbol	MIR7854
Name	microRNA 7854
Location	16q23.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7854
Ensembl gene	ENSG00000277255
Ensembl biotype	miRNA
Entrez	102465840
RNAcentral	URS000075B377 — miRNA, 65 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620068

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620068 — 1 exons

Exon	Start	End
ENSE00003743937	81533902	81533966

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 90.84.

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	90.84	gold quality
sural nerve	UBERON:0015488	85.55	gold quality
blood	UBERON:0000178	81.66	gold quality
endometrium	UBERON:0001295	77.43	gold quality
liver	UBERON:0002107	76.80	gold quality
gastrocnemius	UBERON:0001388	74.40	gold quality
kidney	UBERON:0002113	73.62	gold quality
stomach	UBERON:0000945	73.54	gold quality
monocyte	CL:0000576	73.12	gold quality
heart left ventricle	UBERON:0002084	71.31	gold quality
adult mammalian kidney	UBERON:0000082	70.84	gold quality
body of pancreas	UBERON:0001150	70.71	gold quality
body of stomach	UBERON:0001161	69.34	gold quality
right adrenal gland	UBERON:0001233	68.65	gold quality
right lobe of liver	UBERON:0001114	68.29	gold quality
nucleus accumbens	UBERON:0001882	68.03	gold quality
heart	UBERON:0000948	68.01	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.84	gold quality
left adrenal gland cortex	UBERON:0035825	67.68	gold quality
colon	UBERON:0001155	67.62	gold quality
esophagus mucosa	UBERON:0002469	67.30	gold quality
left coronary artery	UBERON:0001626	66.86	gold quality
intestine	UBERON:0000160	66.79	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.75	gold quality
transverse colon	UBERON:0001157	66.73	gold quality
left adrenal gland	UBERON:0001234	66.51	gold quality
anterior cingulate cortex	UBERON:0009835	66.48	gold quality
ectocervix	UBERON:0012249	66.30	gold quality
lung	UBERON:0002048	66.27	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.