MIR7856

Summary

MIR7856 (microRNA 7856, HGNC:50268) is a microRNA gene on chromosome 1p22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465842 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50268
Approved symbol	MIR7856
Name	microRNA 7856
Location	1p22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7856
Ensembl gene	ENSG00000278281
Ensembl biotype	miRNA
Entrez	102465842
RNAcentral	URS000075A368 — ncRNA, 56 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618009

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618009 — 1 exons

Exon	Start	End
ENSE00003714542	86357632	86357687

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 93.40.

Top tissues by expression

105 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	93.40	gold quality
vermiform appendix	UBERON:0001154	85.73	gold quality
endometrium	UBERON:0001295	83.45	gold quality
duodenum	UBERON:0002114	83.07	gold quality
adrenal tissue	UBERON:0018303	80.84	gold quality
muscle of leg	UBERON:0001383	80.82	gold quality
bone marrow	UBERON:0002371	79.32	gold quality
placenta	UBERON:0001987	79.25	gold quality
gall bladder	UBERON:0002110	78.35	gold quality
lymph node	UBERON:0000029	77.88	gold quality
rectum	UBERON:0001052	77.60	gold quality
right uterine tube	UBERON:0001302	76.43	gold quality
blood	UBERON:0000178	76.17	gold quality
metanephros cortex	UBERON:0010533	76.08	gold quality
gastrocnemius	UBERON:0001388	75.77	gold quality
corpus callosum	UBERON:0002336	74.65	gold quality
body of uterus	UBERON:0009853	74.29	gold quality
left uterine tube	UBERON:0001303	74.27	gold quality
ectocervix	UBERON:0012249	74.27	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.18	gold quality
fallopian tube	UBERON:0003889	74.17	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.12	gold quality
right lobe of thyroid gland	UBERON:0001119	74.10	gold quality
islet of Langerhans	UBERON:0000006	73.96	gold quality
pancreas	UBERON:0001264	73.16	gold quality
monocyte	CL:0000576	73.11	gold quality
right ovary	UBERON:0002118	73.03	gold quality
apex of heart	UBERON:0002098	72.99	gold quality
body of pancreas	UBERON:0001150	72.83	gold quality
kidney	UBERON:0002113	72.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.78

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.