MIR7973-1

Summary

MIR7973-1 (microRNA 7973-1, HGNC:50040) is a microRNA gene on chromosome 15q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466250 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50040
Approved symbol	MIR7973-1
Name	microRNA 7973-1
Location	15q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7973-1
Ensembl gene	ENSG00000278098
Ensembl biotype	miRNA
Entrez	102466250
RNAcentral	URS000075DC59 — miRNA, 76 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614683

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614683 — 1 exons

Exon	Start	End
ENSE00003731901	51314034	51314109

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 78.50.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	78.50	gold quality
omental fat pad	UBERON:0010414	69.23	gold quality
prostate gland	UBERON:0002367	67.38	gold quality
transverse colon	UBERON:0001157	66.21	gold quality
intestine	UBERON:0000160	64.49	gold quality
skin of abdomen	UBERON:0001416	63.77	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.76	gold quality
skin of leg	UBERON:0001511	62.17	gold quality
esophagus mucosa	UBERON:0002469	61.10	gold quality
body of uterus	UBERON:0009853	58.49	gold quality
right frontal lobe	UBERON:0002810	57.78	gold quality
tibial nerve	UBERON:0001323	57.11	gold quality
urinary bladder	UBERON:0001255	56.77	gold quality
small intestine Peyer’s patch	UBERON:0003454	56.12	gold quality
vagina	UBERON:0000996	54.51	gold quality
right testis	UBERON:0004534	48.32	gold quality
left lobe of thyroid gland	UBERON:0001120	47.60	gold quality
left testis	UBERON:0004533	42.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Target prediction and validation of microRNAs expressed from FSHR and aromatase genes in human ovarian granulosa cells. (PMID:32042028)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.