MIR7973-2

Summary

MIR7973-2 (microRNA 7973-2, HGNC:50080) is a microRNA gene on chromosome 15q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465855 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50080
Approved symbol	MIR7973-2
Name	microRNA 7973-2
Location	15q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7973-2
Ensembl gene	ENSG00000283614
Ensembl biotype	miRNA
Entrez	102465855
RNAcentral	URS000075D294 — miRNA, 76 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000635975

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000635975 — 1 exons

Exon	Start	End
ENSE00003798981	51314032	51314107

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 85.27.

Top tissues by expression

37 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	85.27	silver quality
skeletal muscle tissue	UBERON:0001134	80.69	silver quality
bone marrow	UBERON:0002371	80.62	silver quality
kidney	UBERON:0002113	80.43	silver quality
pancreas	UBERON:0001264	79.45	silver quality
quadriceps femoris	UBERON:0001377	78.66	gold quality
caudate nucleus	UBERON:0001873	77.78	gold quality
cerebellar vermis	UBERON:0004720	77.12	gold quality
anterior cingulate cortex	UBERON:0009835	77.11	gold quality
spleen	UBERON:0002106	76.50	silver quality
heart	UBERON:0000948	76.09	silver quality
lung	UBERON:0002048	75.24	silver quality
spinal cord	UBERON:0002240	74.60	silver quality
monocyte	CL:0000576	72.58	gold quality
transverse colon	UBERON:0001157	66.40	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.07	gold quality
thymus	UBERON:0002370	65.74	silver quality
skin of abdomen	UBERON:0001416	65.25	gold quality
brain	UBERON:0000955	64.80	gold quality
zone of skin	UBERON:0000014	64.36	gold quality
frontal cortex	UBERON:0001870	63.59	gold quality
skin of leg	UBERON:0001511	63.27	gold quality
Ammon’s horn	UBERON:0001954	62.83	gold quality
esophagus mucosa	UBERON:0002469	62.38	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.16	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.14	gold quality
right frontal lobe	UBERON:0002810	62.11	gold quality
prostate gland	UBERON:0002367	60.91	gold quality
vagina	UBERON:0000996	59.32	gold quality
body of uterus	UBERON:0009853	58.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.05

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Target prediction and validation of microRNAs expressed from FSHR and aromatase genes in human ovarian granulosa cells. (PMID:32042028)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.