MIR7974

Summary

MIR7974 (microRNA 7974, HGNC:49992) is a microRNA gene on chromosome 19p13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465856 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49992
Approved symbol	MIR7974
Name	microRNA 7974
Location	19p13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7974
Ensembl gene	ENSG00000274713
Ensembl biotype	miRNA
Entrez	102465856
RNAcentral	URS000075C799 — ncRNA, 79 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000615835

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615835 — 1 exons

Exon	Start	End
ENSE00003735508	11495544	11495622

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 85.49.

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	85.49	gold quality
duodenum	UBERON:0002114	83.50	gold quality
monocyte	CL:0000576	77.01	gold quality
blood	UBERON:0000178	76.04	gold quality
adrenal tissue	UBERON:0018303	74.64	gold quality
muscle of leg	UBERON:0001383	74.30	gold quality
prefrontal cortex	UBERON:0000451	73.94	gold quality
endocervix	UBERON:0000458	73.21	gold quality
gastrocnemius	UBERON:0001388	72.57	gold quality
islet of Langerhans	UBERON:0000006	72.11	gold quality
kidney	UBERON:0002113	71.73	gold quality
tonsil	UBERON:0002372	71.41	gold quality
heart left ventricle	UBERON:0002084	71.02	gold quality
gall bladder	UBERON:0002110	69.97	gold quality
endometrium	UBERON:0001295	69.86	gold quality
right adrenal gland cortex	UBERON:0035827	69.68	gold quality
right adrenal gland	UBERON:0001233	69.23	gold quality
left coronary artery	UBERON:0001626	69.22	gold quality
metanephros cortex	UBERON:0010533	69.14	gold quality
body of stomach	UBERON:0001161	68.68	gold quality
fundus of stomach	UBERON:0001160	68.30	gold quality
stomach	UBERON:0000945	68.05	gold quality
body of pancreas	UBERON:0001150	67.92	gold quality
adrenal gland	UBERON:0002369	67.76	gold quality
thoracic aorta	UBERON:0001515	67.58	gold quality
ascending aorta	UBERON:0001496	67.31	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.23	gold quality
myometrium	UBERON:0001296	66.98	gold quality
tibial artery	UBERON:0007610	66.96	gold quality
popliteal artery	UBERON:0002250	66.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.13

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.