MIR7975

Summary

MIR7975 (microRNA 7975, HGNC:49967) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466872 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49967
Approved symbol	MIR7975
Name	microRNA 7975
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7975
Ensembl gene	ENSG00000275863
Ensembl biotype	miRNA
Entrez	102466872
RNAcentral	URS000075D038 — miRNA, 68 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619350

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619350 — 1 exons

Exon	Start	End
ENSE00003735427	55123225	55123292

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 86.88.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.88	gold quality
apex of heart	UBERON:0002098	79.83	gold quality
muscle of leg	UBERON:0001383	74.88	gold quality
gastrocnemius	UBERON:0001388	74.71	gold quality
heart	UBERON:0000948	72.10	gold quality
heart left ventricle	UBERON:0002084	70.60	gold quality
right atrium auricular region	UBERON:0006631	70.59	gold quality
body of stomach	UBERON:0001161	66.20	gold quality
transverse colon	UBERON:0001157	65.82	gold quality
ectocervix	UBERON:0012249	65.47	gold quality
tibial artery	UBERON:0007610	65.43	gold quality
skin of leg	UBERON:0001511	65.16	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.35	gold quality
cerebellar hemisphere	UBERON:0002245	62.80	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	62.28	gold quality
esophagus mucosa	UBERON:0002469	61.00	gold quality
thoracic mammary gland	UBERON:0005200	54.25	gold quality
left testis	UBERON:0004533	43.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.26

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.