MIR7976

Summary

MIR7976 (microRNA 7976, HGNC:50092) is a microRNA gene on chromosome 3q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465857 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50092
Approved symbol	MIR7976
Name	microRNA 7976
Location	3q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7976
Ensembl gene	ENSG00000276083
Ensembl biotype	miRNA
Entrez	102465857
RNAcentral	URS000075EFB5 — ncRNA, 66 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614175

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614175 — 1 exons

Exon	Start	End
ENSE00003726163	127587111	127587176

Expression profiles

Bgee: expression breadth broad, 61 present calls, max score 94.40.

Top tissues by expression

61 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	94.40	gold quality
bone marrow	UBERON:0002371	80.33	gold quality
blood	UBERON:0000178	75.48	gold quality
islet of Langerhans	UBERON:0000006	73.40	gold quality
right lobe of thyroid gland	UBERON:0001119	73.28	gold quality
gastrocnemius	UBERON:0001388	72.38	gold quality
endometrium	UBERON:0001295	72.11	gold quality
heart left ventricle	UBERON:0002084	72.06	gold quality
monocyte	CL:0000576	71.87	gold quality
transverse colon	UBERON:0001157	69.91	gold quality
Ammon’s horn	UBERON:0001954	69.73	gold quality
fundus of stomach	UBERON:0001160	69.23	gold quality
heart	UBERON:0000948	68.57	gold quality
body of stomach	UBERON:0001161	67.91	gold quality
right coronary artery	UBERON:0001625	67.89	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.24	gold quality
ascending aorta	UBERON:0001496	67.15	gold quality
tibial artery	UBERON:0007610	67.02	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.89	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.77	gold quality
right atrium auricular region	UBERON:0006631	66.55	gold quality
left adrenal gland	UBERON:0001234	66.41	gold quality
thoracic aorta	UBERON:0001515	66.28	gold quality
omental fat pad	UBERON:0010414	65.75	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.66	gold quality
skin of abdomen	UBERON:0001416	65.65	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.45	gold quality
esophagus mucosa	UBERON:0002469	65.21	gold quality
urinary bladder	UBERON:0001255	65.20	gold quality
zone of skin	UBERON:0000014	64.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.