MIR7977

Summary

MIR7977 (microRNA 7977, HGNC:49969) is a microRNA gene on chromosome 3q26.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465858 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49969
Approved symbol	MIR7977
Name	microRNA 7977
Location	3q26.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7977
Ensembl gene	ENSG00000283333
Ensembl biotype	miRNA
Entrez	102465858
RNAcentral	URS000075B033 — miRNA, 49 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636162

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636162 — 1 exons

Exon	Start	End
ENSE00003796633	176515103	176515151

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 82.16.

Top tissues by expression

8 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colon	UBERON:0001155	82.16	gold quality
heart	UBERON:0000948	76.09	gold quality
minor salivary gland	UBERON:0001830	68.02	gold quality
skin of leg	UBERON:0001511	67.51	gold quality
cerebellar hemisphere	UBERON:0002245	64.75	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.99	gold quality
skin of abdomen	UBERON:0001416	61.74	gold quality
left testis	UBERON:0004533	49.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• miR-7977 in extracellular vesicles may be a critical factor that induces failure of normal hematopoiesis via poly(rC) binding protein 1 suppression in myeloid neoplasms. (PMID:26802051)
• miR-7977-transduced mesenchymal stromal cell line, HTS-5, showed elevated saturation density and enhanced entry into the cell cycle (PMID:30835743)
• Serum exosomal miR-7977 as a novel biomarker for lung adenocarcinoma. (PMID:31898829)
• Overexpression of miR-7977 in CD4+ T cells is associated with multiplex autoimmunity in patients with Addison’s disease. (PMID:33960958)
• Plasma exosomal miR-1260a, miR-7977 and miR-192-5p as diagnostic biomarkers in epithelial ovarian cancer. (PMID:35893704)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.