MIR7978

Summary

MIR7978 (microRNA 7978, HGNC:50113) is a microRNA gene on chromosome 4p15.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465859 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50113
Approved symbol	MIR7978
Name	microRNA 7978
Location	4p15.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7978
Ensembl gene	ENSG00000283281
Ensembl biotype	miRNA
Entrez	102465859
RNAcentral	URS000075C71C — miRNA, 59 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636158

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636158 — 1 exons

Exon	Start	End
ENSE00003797969	21464700	21464758

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 86.19.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	86.19	gold quality
stomach	UBERON:0000945	80.85	gold quality
kidney	UBERON:0002113	80.82	gold quality
lung	UBERON:0002048	80.26	gold quality
corpus callosum	UBERON:0002336	79.92	gold quality
intestine	UBERON:0000160	76.49	gold quality
prefrontal cortex	UBERON:0000451	74.91	gold quality
gastrocnemius	UBERON:0001388	73.03	gold quality
adult mammalian kidney	UBERON:0000082	72.46	gold quality
blood	UBERON:0000178	72.22	gold quality
monocyte	CL:0000576	71.86	gold quality
endometrium	UBERON:0001295	70.30	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.61	gold quality
anterior cingulate cortex	UBERON:0009835	66.85	gold quality
frontal cortex	UBERON:0001870	66.35	gold quality
putamen	UBERON:0001874	66.33	gold quality
brain	UBERON:0000955	66.20	gold quality
amygdala	UBERON:0001876	66.05	gold quality
caudate nucleus	UBERON:0001873	65.88	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.37	gold quality
right frontal lobe	UBERON:0002810	65.28	gold quality
body of uterus	UBERON:0009853	65.03	gold quality
cerebellar hemisphere	UBERON:0002245	64.91	gold quality
Ammon’s horn	UBERON:0001954	64.89	gold quality
nucleus accumbens	UBERON:0001882	64.86	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.47	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.16	gold quality
colon	UBERON:0001155	63.13	gold quality
vagina	UBERON:0000996	62.91	gold quality
pituitary gland	UBERON:0000007	59.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Circular RNA HSDL2 promotes breast cancer progression via miR-7978 ZNF704 axis and regulating hippo signaling pathway. (PMID:38937788)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.