MIR802

Summary

MIR802 (microRNA 802, HGNC:33140) is a microRNA gene on chromosome 21q22.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 768219 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33140
Approved symbol	MIR802
Name	microRNA 802
Location	21q22.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-802
Ensembl gene	ENSG00000211590
Ensembl biotype	miRNA
OMIM	616090
Entrez	768219
RNAcentral	URS000070FC11 — miRNA, 94 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390235

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390235 — 1 exons

Exon	Start	End
ENSE00001507662	35720715	35720808

Expression profiles

Bgee: expression breadth broad, 33 present calls, max score 85.75.

Top tissues by expression

33 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	85.75	gold quality
corpus callosum	UBERON:0002336	82.43	gold quality
small intestine	UBERON:0002108	78.09	gold quality
heart	UBERON:0000948	78.06	gold quality
intestine	UBERON:0000160	76.30	gold quality
pancreas	UBERON:0001264	75.92	gold quality
body of pancreas	UBERON:0001150	75.66	gold quality
muscle of leg	UBERON:0001383	74.97	gold quality
blood	UBERON:0000178	74.73	gold quality
stomach	UBERON:0000945	73.45	gold quality
calcaneal tendon	UBERON:0003701	71.45	gold quality
ascending aorta	UBERON:0001496	70.08	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.55	gold quality
caudate nucleus	UBERON:0001873	67.95	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.93	gold quality
body of uterus	UBERON:0009853	66.41	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.25	gold quality
left ovary	UBERON:0002119	65.04	gold quality
esophagus mucosa	UBERON:0002469	64.98	gold quality
omental fat pad	UBERON:0010414	64.92	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.79	gold quality
right ovary	UBERON:0002118	64.48	gold quality
minor salivary gland	UBERON:0001830	63.91	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.64	gold quality
skin of abdomen	UBERON:0001416	62.87	gold quality
tibial nerve	UBERON:0001323	62.42	gold quality
nucleus accumbens	UBERON:0001882	62.35	gold quality
skin of leg	UBERON:0001511	62.24	gold quality
spleen	UBERON:0002106	60.47	gold quality
colon	UBERON:0001155	58.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 28)

• P-2 and P-27-5p are novel miRNAs, and that CREB3L3, which encodes cAMP-responsive element binding protein 3-like 3, is a target gene of P-2, whereas LAMB3, which encodes laminin beta3, is a target gene of P-27-5p. (PMID:18952845)
• These results suggest that miR-802 can modulate the expression of the hAT(1)R in the GI tract and ultimately play a role in regulating the biological efficacy of Ang II in this system. (PMID:20558762)
• High expression of miR-802 is associated with osteosarcoma. (PMID:24460254)
• These results demonstrate that the NF-kappab/miR-802/PTEN signaling pathway plays an important role in the development of cholesteatoma. (PMID:24867318)
• miR-802 expression levels are increased in lung carcinoma tissues and targets the tumor suppressor menin and downregulates its expression. (PMID:24994111)
• The circulating miR-101, miR-375 and miR-802 levels are significantly increased in T2D patients versus normal glucose tolerance subjects and they may become the new biomarkers for type 2 diabetes. (PMID:25726255)
• MicroRNA-802 suppresses breast cancer proliferation through down-regulation of FoxM1. (PMID:26080894)
• the expression level of MAP2K4 was inversely associated with the expression of miR-802 in tongue squamous cell carcinoma (TSCC) tissues; demonstration that the MAP2K4 expression was upregulated in TSCC cell lines; elevated expression of miR-802 inhibited TSCC cell viability and invasion through inhibiting MAP2K4 expression (PMID:28319306)
• Overexpression of miR-802 repressed RAB23 expression at both mRNA and protein levels by direct target of miR-802 in gastric cancer cells. (PMID:29028094)
• showed that miR-802 expression was enhanced in oral keratinocytes from vitamin D receptor (VDR)(-/-) mice, and an inverse correlation between VDR and miR-802 was found in human biopsy specimens of oral lichen planus (PMID:30074824)
• Low miR-802 expression is associated with cervical cancer. (PMID:30565744)
• High mir802 expression is associated with obesity induced nephropathy. (PMID:30729676)
• Long noncoding RNA MIR155HG facilitates pancreatic cancer progression through negative regulation of miR-802. (PMID:31161625)
• MicroRNA-802 induces hepatitis B virus replication and replication through regulating SMARCE1 expression in hepatocellular carcinoma. (PMID:31611549)
• miR-802 can regulate the occurrence and development of epithelial ovarian cancer by targeting YWHAZ. (PMID:31640760)
• MiR-802 alleviates lipopolysaccharide-induced acute lung injury by targeting Peli2. (PMID:31696241)
• The cAMP-regulated phosphoprotein 19 (ARPP19) was a direct target of miR-802 and could reverse the inhibitory function of miR-802. These data suggest that the IGFL2-AS1/miR-802/ARPP19 axis plays a critical role in the progression and metastasis of gastric cancer. (PMID:31943339)
• microRNA-802 accelerates hepatocellular carcinoma growth by targeting RUNX3. (PMID:32003017)
• MiRNA-802 inhibits the metastasis of colorectal cancer by targeting FOXE1. (PMID:32141546)
• Long non-coding RNA MIR4435-2HG recruits miR-802 from FLOT2 to promote melanoma progression. (PMID:32196611)
• Regulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells. (PMID:32210368)
• MiR-802 inhibits the malignant biological behavior of oral squamous cell carcinoma by targeting proto-oncogene MET. (PMID:32373961)
• miR802 inhibits the epithelialmesenchymal transition, migration and invasion of cervical cancer by regulating BTF3. (PMID:32582971)
• MicroRNA-802 promotes the progression of osteosarcoma through targeting p27 and activating PI3K/AKT pathway. (PMID:34318428)
• miR-802 Suppresses Acinar-to-Ductal Reprogramming During Early Pancreatitis and Pancreatic Carcinogenesis. (PMID:34547282)
• Dysfunction of miR-802 in tumors. (PMID:34558723)
• The novel circ_0084904/miR-802/MAL2 axis promotes the development of cervical cancer. (PMID:35033901)
• Obesity-induced miR-802 directly targets AMPK and promotes nonalcoholic steatohepatitis in mice. (PMID:36126896)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	Mir802	ENSRNOG00000040376

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.