MIR8052

Summary

MIR8052 (microRNA 8052, HGNC:50252) is a microRNA gene on chromosome 11q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466873 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50252
Approved symbol	MIR8052
Name	microRNA 8052
Location	11q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8052
Ensembl gene	ENSG00000274999
Ensembl biotype	miRNA
Entrez	102466873
RNAcentral	URS000075DDA0 — ncRNA, 69 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000615217

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615217 — 1 exons

Exon	Start	End
ENSE00003748132	130666735	130666803

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 78.59.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	78.59	gold quality
gall bladder	UBERON:0002110	71.51	gold quality
tibial artery	UBERON:0007610	71.49	gold quality
subcutaneous adipose tissue	UBERON:0002190	70.00	gold quality
heart left ventricle	UBERON:0002084	68.78	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.54	gold quality
substantia nigra	UBERON:0002038	67.17	gold quality
skin of leg	UBERON:0001511	67.05	gold quality
left ovary	UBERON:0002119	65.62	gold quality
minor salivary gland	UBERON:0001830	65.55	gold quality
omental fat pad	UBERON:0010414	65.10	gold quality
left lobe of thyroid gland	UBERON:0001120	64.92	gold quality
thyroid gland	UBERON:0002046	61.40	gold quality
pituitary gland	UBERON:0000007	59.32	gold quality
tibial nerve	UBERON:0001323	55.20	gold quality
left testis	UBERON:0004533	41.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.10

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.