MIR8053

Summary

MIR8053 (microRNA 8053, HGNC:50137) is a microRNA gene on chromosome 4p12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102467004 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50137
Approved symbol	MIR8053
Name	microRNA 8053
Location	4p12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8053
Ensembl gene	ENSG00000277388
Ensembl biotype	miRNA
Entrez	102467004
RNAcentral	URS000075A757 — ncRNA, 75 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613344

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613344 — 1 exons

Exon	Start	End
ENSE00003752910	47652669	47652743

Expression profiles

Bgee: expression breadth broad, 53 present calls, max score 84.26.

Top tissues by expression

53 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	84.26	gold quality
blood	UBERON:0000178	75.22	gold quality
apex of heart	UBERON:0002098	74.49	gold quality
stomach	UBERON:0000945	74.48	gold quality
heart	UBERON:0000948	74.46	gold quality
right atrium auricular region	UBERON:0006631	72.58	gold quality
heart left ventricle	UBERON:0002084	72.50	gold quality
intestine	UBERON:0000160	71.99	gold quality
myometrium	UBERON:0001296	69.43	gold quality
gall bladder	UBERON:0002110	67.14	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.91	gold quality
esophagus mucosa	UBERON:0002469	66.57	gold quality
substantia nigra	UBERON:0002038	66.08	gold quality
tibial artery	UBERON:0007610	66.03	gold quality
Ammon’s horn	UBERON:0001954	65.77	gold quality
ascending aorta	UBERON:0001496	65.68	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.68	gold quality
skin of abdomen	UBERON:0001416	65.56	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.01	gold quality
vagina	UBERON:0000996	64.93	gold quality
skin of leg	UBERON:0001511	64.93	gold quality
adenohypophysis	UBERON:0002196	64.55	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.53	gold quality
amygdala	UBERON:0001876	64.25	gold quality
urinary bladder	UBERON:0001255	63.98	gold quality
putamen	UBERON:0001874	63.52	gold quality
endocervix	UBERON:0000458	63.36	gold quality
prostate gland	UBERON:0002367	63.17	gold quality
omental fat pad	UBERON:0010414	62.22	gold quality
right ovary	UBERON:0002118	62.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.