MIR8054

Summary

MIR8054 (microRNA 8054, HGNC:50177) is a microRNA gene on chromosome 11p14.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465860 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50177
Approved symbol	MIR8054
Name	microRNA 8054
Location	11p14.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8054
Ensembl gene	ENSG00000275868
Ensembl biotype	miRNA
Entrez	102465860
RNAcentral	URS000075EA0E — ncRNA, 86 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620877

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620877 — 1 exons

Exon	Start	End
ENSE00003745434	23419105	23419190

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 83.03.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	83.03	gold quality
adrenal tissue	UBERON:0018303	81.47	gold quality
tibial artery	UBERON:0007610	71.53	gold quality
corpus callosum	UBERON:0002336	68.78	gold quality
stomach	UBERON:0000945	67.56	gold quality
caudate nucleus	UBERON:0001873	66.59	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.23	gold quality
transverse colon	UBERON:0001157	65.10	gold quality
lung	UBERON:0002048	63.60	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.67	gold quality
thyroid gland	UBERON:0002046	61.59	gold quality
left coronary artery	UBERON:0001626	61.32	gold quality
upper lobe of left lung	UBERON:0008952	60.73	gold quality
spleen	UBERON:0002106	60.26	gold quality
right frontal lobe	UBERON:0002810	54.21	gold quality
left testis	UBERON:0004533	45.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.