MIR8055

Summary

MIR8055 (microRNA 8055, HGNC:50241) is a microRNA gene on chromosome 8p23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465861 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50241
Approved symbol	MIR8055
Name	microRNA 8055
Location	8p23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8055
Ensembl gene	ENSG00000276580
Ensembl biotype	miRNA
Entrez	102465861
RNAcentral	URS000075A786 — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000610739

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000610739 — 1 exons

Exon	Start	End
ENSE00003745595	6622124	6622220

Expression profiles

Bgee: expression breadth ubiquitous, 106 present calls, max score 90.27.

Top tissues by expression

106 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	90.27	gold quality
adrenal tissue	UBERON:0018303	80.26	gold quality
lower esophagus mucosa	UBERON:0035834	78.22	gold quality
calcaneal tendon	UBERON:0003701	78.12	gold quality
urinary bladder	UBERON:0001255	77.69	gold quality
bone marrow	UBERON:0002371	77.22	gold quality
right uterine tube	UBERON:0001302	76.42	gold quality
blood	UBERON:0000178	76.41	gold quality
monocyte	CL:0000576	76.26	gold quality
leukocyte	CL:0000738	75.44	gold quality
islet of Langerhans	UBERON:0000006	75.08	gold quality
endometrium	UBERON:0001295	74.79	gold quality
skeletal muscle tissue	UBERON:0001134	74.78	gold quality
placenta	UBERON:0001987	73.88	gold quality
muscle of leg	UBERON:0001383	73.82	gold quality
gastrocnemius	UBERON:0001388	73.55	gold quality
body of pancreas	UBERON:0001150	72.80	gold quality
heart left ventricle	UBERON:0002084	72.66	gold quality
popliteal artery	UBERON:0002250	72.57	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.57	gold quality
tibial artery	UBERON:0007610	72.53	gold quality
liver	UBERON:0002107	72.24	gold quality
ectocervix	UBERON:0012249	72.15	gold quality
heart	UBERON:0000948	72.09	gold quality
left coronary artery	UBERON:0001626	71.82	gold quality
stomach	UBERON:0000945	71.79	gold quality
right coronary artery	UBERON:0001625	71.61	gold quality
body of stomach	UBERON:0001161	71.51	gold quality
endocervix	UBERON:0000458	71.33	gold quality
right atrium auricular region	UBERON:0006631	71.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Circular RNA circACSL1 aggravated myocardial inflammation and myocardial injury by sponging miR-8055 and regulating MAPK14 expression. (PMID:33986259)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.