MIR8057

Summary

MIR8057 (microRNA 8057, HGNC:49960) is a microRNA gene on chromosome 18q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466874 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49960
Approved symbol	MIR8057
Name	microRNA 8057
Location	18q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8057
Ensembl gene	ENSG00000276221
Ensembl biotype	miRNA
Entrez	102466874
RNAcentral	URS000075BB17 — ncRNA, 69 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620957

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620957 — 1 exons

Exon	Start	End
ENSE00003724879	26591467	26591535

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 94.98.

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	94.98	gold quality
monocyte	CL:0000576	79.60	gold quality
lung	UBERON:0002048	77.45	gold quality
kidney	UBERON:0002113	77.45	gold quality
adrenal tissue	UBERON:0018303	77.40	gold quality
stomach	UBERON:0000945	77.17	gold quality
calcaneal tendon	UBERON:0003701	76.78	gold quality
body of stomach	UBERON:0001161	73.89	gold quality
corpus callosum	UBERON:0002336	72.82	gold quality
heart	UBERON:0000948	70.71	gold quality
adult mammalian kidney	UBERON:0000082	70.60	gold quality
right atrium auricular region	UBERON:0006631	70.49	gold quality
small intestine	UBERON:0002108	70.34	gold quality
rectum	UBERON:0001052	69.77	gold quality
gastrocnemius	UBERON:0001388	69.14	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.21	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.88	gold quality
intestine	UBERON:0000160	67.65	gold quality
tibial artery	UBERON:0007610	67.57	gold quality
ascending aorta	UBERON:0001496	67.00	gold quality
cerebellar hemisphere	UBERON:0002245	66.97	gold quality
transverse colon	UBERON:0001157	66.87	gold quality
left coronary artery	UBERON:0001626	66.28	gold quality
right frontal lobe	UBERON:0002810	66.11	gold quality
amygdala	UBERON:0001876	65.91	gold quality
skin of leg	UBERON:0001511	65.80	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.67	gold quality
colon	UBERON:0001155	65.62	gold quality
nucleus accumbens	UBERON:0001882	65.58	gold quality
left adrenal gland	UBERON:0001234	65.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.