MIR8058

Summary

MIR8058 (microRNA 8058, HGNC:50018) is a microRNA gene on chromosome 16q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465863 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50018
Approved symbol	MIR8058
Name	microRNA 8058
Location	16q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8058
Ensembl gene	ENSG00000277387
Ensembl biotype	miRNA
Entrez	102465863
RNAcentral	URS000075BACA — miRNA, 89 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000615737

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615737 — 1 exons

Exon	Start	End
ENSE00003752920	82688931	82689019

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 83.43.

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	83.43	gold quality
kidney	UBERON:0002113	80.45	gold quality
blood	UBERON:0000178	80.25	gold quality
muscle of leg	UBERON:0001383	78.93	gold quality
calcaneal tendon	UBERON:0003701	77.92	gold quality
gastrocnemius	UBERON:0001388	74.56	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.56	gold quality
heart left ventricle	UBERON:0002084	72.61	gold quality
apex of heart	UBERON:0002098	72.55	gold quality
adrenal tissue	UBERON:0018303	72.17	gold quality
heart	UBERON:0000948	71.80	gold quality
stomach	UBERON:0000945	71.49	gold quality
endometrium	UBERON:0001295	70.86	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	70.74	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.37	gold quality
right atrium auricular region	UBERON:0006631	69.95	gold quality
tibial artery	UBERON:0007610	69.48	gold quality
skin of abdomen	UBERON:0001416	69.11	gold quality
zone of skin	UBERON:0000014	69.10	gold quality
skin of leg	UBERON:0001511	69.01	gold quality
ascending aorta	UBERON:0001496	68.77	gold quality
thoracic aorta	UBERON:0001515	68.69	gold quality
left coronary artery	UBERON:0001626	68.45	gold quality
multicellular organism	UBERON:0000468	68.10	gold quality
spleen	UBERON:0002106	68.07	gold quality
myometrium	UBERON:0001296	67.89	gold quality
anterior cingulate cortex	UBERON:0009835	67.88	gold quality
putamen	UBERON:0001874	67.83	gold quality
Ammon’s horn	UBERON:0001954	67.72	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.89

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.