MIR8060

Summary

MIR8060 (microRNA 8060, HGNC:50180) is a microRNA gene on chromosome 3q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465864 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50180
Approved symbol	MIR8060
Name	microRNA 8060
Location	3q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8060
Ensembl gene	ENSG00000278103
Ensembl biotype	miRNA
Entrez	102465864
RNAcentral	URS000075AE7B — ncRNA, 76 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000615894

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615894 — 1 exons

Exon	Start	End
ENSE00003747957	96359964	96360039

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 76.74.

Top tissues by expression

7 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	76.74	gold quality
monocyte	CL:0000576	74.37	gold quality
transverse colon	UBERON:0001157	64.72	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.00	gold quality
skin of leg	UBERON:0001511	62.37	gold quality
right frontal lobe	UBERON:0002810	57.78	gold quality
left testis	UBERON:0004533	38.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.