MIR8061

Summary

MIR8061 (microRNA 8061, HGNC:50077) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466251 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50077
Approved symbol	MIR8061
Name	microRNA 8061
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8061
Ensembl gene	ENSG00000277636
Ensembl biotype	miRNA
Entrez	102466251
RNAcentral	URS000075EC42 — miRNA, 75 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618936

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618936 — 1 exons

Exon	Start	End
ENSE00003746720	54645309	54645383

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 77.41.

Top tissues by expression

30 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	77.41	gold quality
blood	UBERON:0000178	77.31	gold quality
stomach	UBERON:0000945	76.91	gold quality
calcaneal tendon	UBERON:0003701	72.25	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	71.07	gold quality
caudate nucleus	UBERON:0001873	69.37	gold quality
esophagus mucosa	UBERON:0002469	68.31	gold quality
adrenal gland	UBERON:0002369	68.03	gold quality
omental fat pad	UBERON:0010414	67.83	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.73	gold quality
granulocyte	CL:0000094	66.67	gold quality
right atrium auricular region	UBERON:0006631	66.55	gold quality
substantia nigra	UBERON:0002038	66.00	gold quality
left adrenal gland	UBERON:0001234	64.42	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.69	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.64	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.15	gold quality
hypothalamus	UBERON:0001898	62.99	gold quality
prostate gland	UBERON:0002367	62.80	gold quality
spleen	UBERON:0002106	62.40	gold quality
transverse colon	UBERON:0001157	61.94	gold quality
right frontal lobe	UBERON:0002810	61.21	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	60.97	gold quality
upper lobe of left lung	UBERON:0008952	60.73	gold quality
left lobe of thyroid gland	UBERON:0001120	59.21	gold quality
thyroid gland	UBERON:0002046	58.19	gold quality
pituitary gland	UBERON:0000007	57.05	gold quality
ovary	UBERON:0000992	50.40	gold quality
testis	UBERON:0000473	45.08	gold quality
left testis	UBERON:0004533	39.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.