MIR8063

Summary

MIR8063 (microRNA 8063, HGNC:50088) is a microRNA gene on chromosome 15q14.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466875 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50088
Approved symbol	MIR8063
Name	microRNA 8063
Location	15q14
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8063
Ensembl gene	ENSG00000277202
Ensembl biotype	miRNA
Entrez	102466875
RNAcentral	URS000075B70B — ncRNA, 81 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621930

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621930 — 1 exons

Exon	Start	End
ENSE00003753287	36972821	36972901

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 86.09.

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	86.09	gold quality
stomach	UBERON:0000945	78.97	gold quality
corpus callosum	UBERON:0002336	78.48	gold quality
kidney	UBERON:0002113	78.09	gold quality
calcaneal tendon	UBERON:0003701	74.99	gold quality
heart	UBERON:0000948	74.69	gold quality
blood	UBERON:0000178	74.00	gold quality
islet of Langerhans	UBERON:0000006	73.62	gold quality
monocyte	CL:0000576	73.34	gold quality
pancreas	UBERON:0001264	72.40	gold quality
lung	UBERON:0002048	72.19	gold quality
liver	UBERON:0002107	71.92	gold quality
placenta	UBERON:0001987	71.40	gold quality
ectocervix	UBERON:0012249	71.24	gold quality
adult mammalian kidney	UBERON:0000082	70.17	gold quality
right lobe of liver	UBERON:0001114	68.96	gold quality
intestine	UBERON:0000160	68.37	gold quality
Ammon’s horn	UBERON:0001954	68.00	gold quality
right atrium auricular region	UBERON:0006631	67.56	gold quality
body of uterus	UBERON:0009853	66.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.74	gold quality
heart left ventricle	UBERON:0002084	66.72	gold quality
body of pancreas	UBERON:0001150	66.34	gold quality
ascending aorta	UBERON:0001496	65.90	gold quality
tibial artery	UBERON:0007610	65.75	gold quality
colon	UBERON:0001155	65.52	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.27	gold quality
putamen	UBERON:0001874	64.95	gold quality
body of stomach	UBERON:0001161	64.85	gold quality
left adrenal gland	UBERON:0001234	64.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.47

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.