MIR8064

Summary

MIR8064 (microRNA 8064, HGNC:50236) is a microRNA gene on chromosome 3p21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465866 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50236
Approved symbol	MIR8064
Name	microRNA 8064
Location	3p21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8064
Ensembl gene	ENSG00000275789
Ensembl biotype	miRNA
Entrez	102465866
RNAcentral	URS000075D104 — miRNA, 90 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612863

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612863 — 1 exons

Exon	Start	End
ENSE00003738684	52846463	52846552

Expression profiles

Bgee: expression breadth broad, 93 present calls, max score 79.11.

Top tissues by expression

93 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	79.11	gold quality
vermiform appendix	UBERON:0001154	77.50	gold quality
monocyte	CL:0000576	77.40	gold quality
muscle of leg	UBERON:0001383	74.51	gold quality
blood	UBERON:0000178	73.94	gold quality
gastrocnemius	UBERON:0001388	73.75	gold quality
adrenal tissue	UBERON:0018303	72.69	gold quality
calcaneal tendon	UBERON:0003701	72.16	gold quality
placenta	UBERON:0001987	71.83	gold quality
fundus of stomach	UBERON:0001160	71.26	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.26	gold quality
tibial artery	UBERON:0007610	70.67	gold quality
endometrium	UBERON:0001295	70.64	gold quality
heart left ventricle	UBERON:0002084	70.51	gold quality
ascending aorta	UBERON:0001496	70.16	gold quality
lymph node	UBERON:0000029	70.07	gold quality
thoracic aorta	UBERON:0001515	69.91	gold quality
stomach	UBERON:0000945	69.88	gold quality
body of pancreas	UBERON:0001150	69.64	gold quality
body of stomach	UBERON:0001161	69.50	gold quality
heart	UBERON:0000948	69.49	gold quality
left coronary artery	UBERON:0001626	69.37	gold quality
adult mammalian kidney	UBERON:0000082	69.35	gold quality
liver	UBERON:0002107	69.34	gold quality
kidney	UBERON:0002113	69.22	gold quality
adrenal gland	UBERON:0002369	69.00	gold quality
right ovary	UBERON:0002118	68.96	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.56	gold quality
right coronary artery	UBERON:0001625	68.48	gold quality
anterior cingulate cortex	UBERON:0009835	68.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.