MIR8065

Summary

MIR8065 (microRNA 8065, HGNC:49959) is a microRNA gene on chromosome 16p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465867 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49959
Approved symbol	MIR8065
Name	microRNA 8065
Location	16p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8065
Ensembl gene	ENSG00000273648
Ensembl biotype	miRNA
Entrez	102465867
RNAcentral	URS000075C2C3 — miRNA, 100 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620577

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620577 — 1 exons

Exon	Start	End
ENSE00003743578	5632467	5632566

Expression profiles

Bgee: expression breadth broad, 22 present calls, max score 80.80.

Top tissues by expression

22 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	80.80	gold quality
lung	UBERON:0002048	78.35	gold quality
adult mammalian kidney	UBERON:0000082	76.08	gold quality
stomach	UBERON:0000945	76.05	gold quality
blood	UBERON:0000178	74.52	gold quality
adrenal tissue	UBERON:0018303	73.09	gold quality
corpus callosum	UBERON:0002336	69.83	gold quality
skin of leg	UBERON:0001511	69.22	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.55	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.71	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.38	gold quality
hypothalamus	UBERON:0001898	64.99	gold quality
amygdala	UBERON:0001876	64.64	gold quality
skin of abdomen	UBERON:0001416	64.43	gold quality
Ammon’s horn	UBERON:0001954	64.30	gold quality
transverse colon	UBERON:0001157	63.78	gold quality
colon	UBERON:0001155	62.37	gold quality
nucleus accumbens	UBERON:0001882	60.89	gold quality
substantia nigra	UBERON:0002038	59.23	gold quality
minor salivary gland	UBERON:0001830	58.80	gold quality
right frontal lobe	UBERON:0002810	50.02	gold quality
right testis	UBERON:0004534	48.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.