MIR8066

Summary

MIR8066 (microRNA 8066, HGNC:50043) is a microRNA gene on chromosome 4q24.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465868 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50043
Approved symbol	MIR8066
Name	microRNA 8066
Location	4q24
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8066
Ensembl gene	ENSG00000273882
Ensembl biotype	miRNA
Entrez	102465868
RNAcentral	URS000075C6A0 — miRNA, 78 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617280

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617280 — 1 exons

Exon	Start	End
ENSE00003752522	101240795	101240872

Expression profiles

Bgee: expression breadth broad, 66 present calls, max score 89.97.

Top tissues by expression

66 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	89.97	gold quality
skeletal muscle tissue	UBERON:0001134	86.64	gold quality
blood	UBERON:0000178	82.72	gold quality
adrenal tissue	UBERON:0018303	81.73	gold quality
calcaneal tendon	UBERON:0003701	79.67	gold quality
muscle of leg	UBERON:0001383	79.63	gold quality
bone marrow	UBERON:0002371	77.55	gold quality
stomach	UBERON:0000945	75.25	gold quality
gastrocnemius	UBERON:0001388	73.70	gold quality
left adrenal gland	UBERON:0001234	73.66	gold quality
liver	UBERON:0002107	73.14	gold quality
adrenal gland	UBERON:0002369	73.05	gold quality
lung	UBERON:0002048	72.45	gold quality
heart	UBERON:0000948	71.05	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.04	gold quality
body of stomach	UBERON:0001161	70.48	gold quality
monocyte	CL:0000576	69.96	gold quality
prefrontal cortex	UBERON:0000451	69.46	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.87	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.74	gold quality
anterior cingulate cortex	UBERON:0009835	68.68	gold quality
fundus of stomach	UBERON:0001160	68.27	gold quality
rectum	UBERON:0001052	67.89	gold quality
Ammon’s horn	UBERON:0001954	67.56	gold quality
nucleus accumbens	UBERON:0001882	67.46	gold quality
right lobe of liver	UBERON:0001114	66.71	gold quality
putamen	UBERON:0001874	66.56	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.43	gold quality
ascending aorta	UBERON:0001496	66.41	gold quality
heart left ventricle	UBERON:0002084	66.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.08

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.