MIR8067

Summary

MIR8067 (microRNA 8067, HGNC:49934) is a microRNA gene on chromosome 15q22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465869 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49934
Approved symbol	MIR8067
Name	microRNA 8067
Location	15q22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8067
Ensembl gene	ENSG00000277919
Ensembl biotype	miRNA
Entrez	102465869
RNAcentral	URS000075CB49 — ncRNA, 77 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618843

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618843 — 1 exons

Exon	Start	End
ENSE00003744991	62304658	62304734

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 87.69.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	87.69	gold quality
nucleus accumbens	UBERON:0001882	83.99	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.90	gold quality
kidney	UBERON:0002113	75.15	gold quality
urinary bladder	UBERON:0001255	74.56	gold quality
endometrium	UBERON:0001295	73.69	gold quality
body of pancreas	UBERON:0001150	72.12	gold quality
substantia nigra	UBERON:0002038	70.40	gold quality
rectum	UBERON:0001052	67.93	gold quality
hypothalamus	UBERON:0001898	67.33	gold quality
omental fat pad	UBERON:0010414	65.13	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.55	gold quality
left lobe of thyroid gland	UBERON:0001120	63.06	gold quality
lung	UBERON:0002048	62.05	gold quality
anterior cingulate cortex	UBERON:0009835	61.74	gold quality
minor salivary gland	UBERON:0001830	61.56	gold quality
Brodmann (1909) area 9	UBERON:0013540	60.98	gold quality
thyroid gland	UBERON:0002046	60.97	gold quality
metanephros cortex	UBERON:0010533	60.65	gold quality
myometrium	UBERON:0001296	60.44	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.15	gold quality
right lobe of thyroid gland	UBERON:0001119	59.61	gold quality
putamen	UBERON:0001874	59.61	gold quality
pituitary gland	UBERON:0000007	59.46	gold quality
adenohypophysis	UBERON:0002196	59.42	gold quality
caudate nucleus	UBERON:0001873	58.74	gold quality
upper lobe of left lung	UBERON:0008952	51.04	gold quality
tibial nerve	UBERON:0001323	50.80	gold quality
testis	UBERON:0000473	44.76	gold quality
right testis	UBERON:0004534	44.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.