MIR8068

Summary

MIR8068 (microRNA 8068, HGNC:50238) is a microRNA gene on chromosome 11p14.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466876 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50238
Approved symbol	MIR8068
Name	microRNA 8068
Location	11p14.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8068
Ensembl gene	ENSG00000273912
Ensembl biotype	miRNA
Entrez	102466876
RNAcentral	URS000075E8E3 — miRNA, 68 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618032

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618032 — 1 exons

Exon	Start	End
ENSE00003714366	28477481	28477548

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 84.26.

Top tissues by expression

56 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	84.26	gold quality
blood	UBERON:0000178	80.19	gold quality
heart	UBERON:0000948	78.04	gold quality
gastrocnemius	UBERON:0001388	77.68	gold quality
adrenal tissue	UBERON:0018303	77.25	gold quality
lung	UBERON:0002048	75.27	gold quality
liver	UBERON:0002107	74.56	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.20	gold quality
monocyte	CL:0000576	74.11	gold quality
calcaneal tendon	UBERON:0003701	71.92	gold quality
stomach	UBERON:0000945	71.41	gold quality
body of stomach	UBERON:0001161	70.18	gold quality
left adrenal gland cortex	UBERON:0035825	69.99	gold quality
thoracic mammary gland	UBERON:0005200	69.89	gold quality
left adrenal gland	UBERON:0001234	69.20	gold quality
adult mammalian kidney	UBERON:0000082	68.21	gold quality
kidney	UBERON:0002113	68.10	gold quality
tibial artery	UBERON:0007610	67.69	gold quality
thoracic aorta	UBERON:0001515	67.50	gold quality
skin of abdomen	UBERON:0001416	67.33	gold quality
intestine	UBERON:0000160	66.97	gold quality
ascending aorta	UBERON:0001496	66.84	gold quality
transverse colon	UBERON:0001157	66.58	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.79	gold quality
colon	UBERON:0001155	65.12	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.09	gold quality
right ovary	UBERON:0002118	64.81	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.79	gold quality
omental fat pad	UBERON:0010414	64.65	gold quality
skin of leg	UBERON:0001511	64.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.27

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.