MIR8069

Summary

MIR8069 (microRNA 8069, HGNC:50836) is a microRNA gene on chromosome 21q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 103504736 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50836
Approved symbol	MIR8069
Name	microRNA 8069
Location	21q11.2
Locus type	RNA, micro
Status	Approved
Ensembl gene	ENSG00000278618
Ensembl biotype	miRNA
Entrez	103504736
RNAcentral	URS000075DDB1 — ncRNA, 86 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621412

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621412 — 1 exons

Exon	Start	End
ENSE00003716433	13724189	13724274

Expression profiles

Bgee: expression breadth broad, 37 present calls, max score 73.89.

Top tissues by expression

37 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	73.89	gold quality
gastrocnemius	UBERON:0001388	71.21	gold quality
monocyte	CL:0000576	71.05	gold quality
body of pancreas	UBERON:0001150	66.03	gold quality
left coronary artery	UBERON:0001626	65.76	gold quality
heart left ventricle	UBERON:0002084	64.70	gold quality
right lobe of liver	UBERON:0001114	62.54	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.85	gold quality
body of stomach	UBERON:0001161	60.83	gold quality
muscle layer of sigmoid colon	UBERON:0035805	59.86	gold quality
transverse colon	UBERON:0001157	59.45	gold quality
esophagus mucosa	UBERON:0002469	59.40	gold quality
skin of abdomen	UBERON:0001416	59.27	gold quality
ascending aorta	UBERON:0001496	59.19	gold quality
right frontal lobe	UBERON:0002810	58.79	gold quality
right atrium auricular region	UBERON:0006631	58.28	gold quality
right hemisphere of cerebellum	UBERON:0014890	58.26	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	57.99	gold quality
left uterine tube	UBERON:0001303	57.00	gold quality
cerebellar hemisphere	UBERON:0002245	56.75	gold quality
minor salivary gland	UBERON:0001830	55.64	gold quality
caudate nucleus	UBERON:0001873	54.78	gold quality
upper lobe of left lung	UBERON:0008952	54.77	gold quality
anterior cingulate cortex	UBERON:0009835	54.33	gold quality
tibial nerve	UBERON:0001323	53.97	gold quality
right lobe of thyroid gland	UBERON:0001119	53.69	gold quality
left adrenal gland	UBERON:0001234	53.59	gold quality
prostate gland	UBERON:0002367	53.43	gold quality
urinary bladder	UBERON:0001255	53.19	gold quality
thyroid gland	UBERON:0002046	52.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (1): hsa-mir-8069-1 (ENSG00000284550)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.