MIR8070

Summary

MIR8070 (microRNA 8070, HGNC:50274) is a microRNA gene on chromosome 11p15.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465870 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50274
Approved symbol	MIR8070
Name	microRNA 8070
Location	11p15.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8070
Ensembl gene	ENSG00000278529
Ensembl biotype	miRNA
Entrez	102465870
RNAcentral	URS000075AB3F — miRNA, 88 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616510

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616510 — 1 exons

Exon	Start	End
ENSE00003713829	11783135	11783222

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 77.22.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
amygdala	UBERON:0001876	77.22	gold quality
heart left ventricle	UBERON:0002084	70.46	gold quality
transverse colon	UBERON:0001157	68.31	gold quality
tibial nerve	UBERON:0001323	66.67	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.68	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.94	gold quality
Ammon’s horn	UBERON:0001954	64.76	gold quality
skin of leg	UBERON:0001511	64.60	gold quality
caudate nucleus	UBERON:0001873	63.84	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.46	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.43	gold quality
nucleus accumbens	UBERON:0001882	63.42	gold quality
prostate gland	UBERON:0002367	62.80	gold quality
anterior cingulate cortex	UBERON:0009835	61.73	gold quality
skin of abdomen	UBERON:0001416	60.88	gold quality
left ovary	UBERON:0002119	57.48	gold quality
pituitary gland	UBERON:0000007	55.62	gold quality
adenohypophysis	UBERON:0002196	53.84	gold quality
left testis	UBERON:0004533	43.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.