MIR8071-2

Summary

MIR8071-2 (microRNA 8071-2, HGNC:49958) is a microRNA gene on chromosome 14q32.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466889 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49958
Approved symbol	MIR8071-2
Name	microRNA 8071-2
Location	14q32.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8071-2
Ensembl gene	ENSG00000277030
Ensembl biotype	miRNA
Entrez	102466889
RNAcentral	URS0000759EF1 — miRNA, 65 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616772

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616772 — 1 exons

Exon	Start	End
ENSE00003739581	105640168	105640232

Expression profiles

Bgee: expression breadth broad, 29 present calls, max score 71.13.

Top tissues by expression

29 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	71.13	gold quality
vermiform appendix	UBERON:0001154	68.40	gold quality
monocyte	CL:0000576	65.58	gold quality
heart left ventricle	UBERON:0002084	64.80	gold quality
blood	UBERON:0000178	63.44	gold quality
spleen	UBERON:0002106	63.08	gold quality
right atrium auricular region	UBERON:0006631	62.71	gold quality
body of stomach	UBERON:0001161	62.13	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	59.64	gold quality
tibial artery	UBERON:0007610	59.27	gold quality
body of uterus	UBERON:0009853	57.66	gold quality
muscle layer of sigmoid colon	UBERON:0035805	57.08	gold quality
colon	UBERON:0001155	56.43	gold quality
Ammon’s horn	UBERON:0001954	56.11	gold quality
substantia nigra	UBERON:0002038	55.57	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	55.57	gold quality
ascending aorta	UBERON:0001496	55.05	gold quality
left lobe of thyroid gland	UBERON:0001120	51.73	gold quality
anterior cingulate cortex	UBERON:0009835	51.13	gold quality
putamen	UBERON:0001874	50.08	gold quality
pituitary gland	UBERON:0000007	49.76	gold quality
minor salivary gland	UBERON:0001830	49.20	gold quality
nucleus accumbens	UBERON:0001882	48.91	gold quality
thoracic mammary gland	UBERON:0005200	47.10	gold quality
prostate gland	UBERON:0002367	46.84	gold quality
transverse colon	UBERON:0001157	45.55	gold quality
small intestine Peyer’s patch	UBERON:0003454	42.29	silver quality
lower esophagus muscularis layer	UBERON:0035833	41.95	silver quality
caudate nucleus	UBERON:0001873	38.83	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (1): MIR8071-1 (ENSG00000274172)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.