MIR8072

Summary

MIR8072 (microRNA 8072, HGNC:50174) is a microRNA gene on chromosome 12q24.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466877 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50174
Approved symbol	MIR8072
Name	microRNA 8072
Location	12q24.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8072
Ensembl gene	ENSG00000284425
Ensembl biotype	miRNA
Entrez	102466877
RNAcentral	URS000075E12A — ncRNA, 80 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614241

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614241 — 1 exons

Exon	Start	End
ENSE00003734142	123364764	123364843

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 87.21.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.1630 / max 134.9962, expressed in 1782 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
133940	13.1630	1782

Top tissues by expression

13 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	87.21	gold quality
liver	UBERON:0002107	82.95	gold quality
placenta	UBERON:0001987	72.29	gold quality
brain	UBERON:0000955	71.86	gold quality
blood	UBERON:0000178	66.96	gold quality
stomach	UBERON:0000945	57.24	gold quality
subcutaneous adipose tissue	UBERON:0002190	55.87	gold quality
skin of leg	UBERON:0001511	53.10	gold quality
left lobe of thyroid gland	UBERON:0001120	50.39	gold quality
body of stomach	UBERON:0001161	50.23	gold quality
body of pancreas	UBERON:0001150	49.65	gold quality
lung	UBERON:0002048	41.84	silver quality
ascending aorta	UBERON:0001496	39.02	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• TFAP2A downregulation mediates tumor-suppressive effect of miR-8072 in triple-negative breast cancer via inhibiting SNAI1 transcription. (PMID:38890750)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.