MIR8073

Summary

MIR8073 (microRNA 8073, HGNC:50131) is a microRNA gene on chromosome 13q34.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465872 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50131
Approved symbol	MIR8073
Name	microRNA 8073
Location	13q34
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8073
Ensembl gene	ENSG00000276765
Ensembl biotype	miRNA
Entrez	102465872
RNAcentral	URS000075E026 — ncRNA, 72 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616690

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616690 — 1 exons

Exon	Start	End
ENSE00003743062	110340958	110341029

Expression profiles

Bgee: expression breadth broad, 66 present calls, max score 94.48.

Top tissues by expression

66 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	94.48	gold quality
adrenal tissue	UBERON:0018303	80.93	gold quality
kidney	UBERON:0002113	75.37	gold quality
muscle of leg	UBERON:0001383	74.71	gold quality
liver	UBERON:0002107	74.65	gold quality
gastrocnemius	UBERON:0001388	73.17	gold quality
heart left ventricle	UBERON:0002084	72.64	gold quality
right adrenal gland cortex	UBERON:0035827	72.21	gold quality
heart	UBERON:0000948	71.97	gold quality
blood	UBERON:0000178	71.96	gold quality
stomach	UBERON:0000945	71.79	gold quality
monocyte	CL:0000576	71.53	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.41	gold quality
lung	UBERON:0002048	71.06	gold quality
endometrium	UBERON:0001295	70.52	gold quality
rectum	UBERON:0001052	69.35	gold quality
urinary bladder	UBERON:0001255	69.26	gold quality
left coronary artery	UBERON:0001626	69.03	gold quality
descending thoracic aorta	UBERON:0002345	68.35	gold quality
right atrium auricular region	UBERON:0006631	68.15	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.12	gold quality
ascending aorta	UBERON:0001496	67.98	gold quality
thoracic aorta	UBERON:0001515	67.95	gold quality
tibial artery	UBERON:0007610	67.63	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.30	gold quality
intestine	UBERON:0000160	67.25	gold quality
body of stomach	UBERON:0001161	67.16	gold quality
lower esophagus	UBERON:0013473	66.93	gold quality
caudate nucleus	UBERON:0001873	66.92	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiRNA-8073 targets ZnT1 to inhibit malignant progression of ovarian cancer. (PMID:31364107)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.