MIR8074

Summary

MIR8074 (microRNA 8074, HGNC:50105) is a microRNA gene on chromosome 19q13.41.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465873 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50105
Approved symbol	MIR8074
Name	microRNA 8074
Location	19q13.41
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8074
Ensembl gene	ENSG00000278617
Ensembl biotype	miRNA
Entrez	102465873
RNAcentral	URS000075F0A1 — miRNA, 81 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000615081

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615081 — 1 exons

Exon	Start	End
ENSE00003730092	51206929	51207009

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 72.59.

Top tissues by expression

7 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	72.59	gold quality
thyroid gland	UBERON:0002046	66.22	gold quality
spleen	UBERON:0002106	64.11	gold quality
lung	UBERON:0002048	58.96	gold quality
testis	UBERON:0000473	46.77	gold quality
right testis	UBERON:0004534	46.49	gold quality
left testis	UBERON:0004533	45.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Circulating Serum MiRNA-8074 as a Novel Prognostic Biomarker for Multiple Myeloma. (PMID:35203396)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.