MIR8075

Summary

MIR8075 (microRNA 8075, HGNC:50172) is a microRNA gene on chromosome 13q34.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465874 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50172
Approved symbol	MIR8075
Name	microRNA 8075
Location	13q34
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8075
Ensembl gene	ENSG00000277942
Ensembl biotype	miRNA
Entrez	102465874
RNAcentral	URS000075A5D9 — ncRNA, 80 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614354

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614354 — 1 exons

Exon	Start	End
ENSE00003726911	113262920	113262999

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 96.49.

Top tissues by expression

114 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	96.49	gold quality
adrenal tissue	UBERON:0018303	94.41	gold quality
right testis	UBERON:0004534	94.21	gold quality
testis	UBERON:0000473	94.04	gold quality
left testis	UBERON:0004533	93.85	gold quality
endometrium	UBERON:0001295	91.83	gold quality
skeletal muscle tissue	UBERON:0001134	91.09	gold quality
apex of heart	UBERON:0002098	90.14	gold quality
smooth muscle tissue	UBERON:0001135	89.46	gold quality
minor salivary gland	UBERON:0001830	89.18	gold quality
liver	UBERON:0002107	89.17	gold quality
saliva-secreting gland	UBERON:0001044	88.91	gold quality
prefrontal cortex	UBERON:0000451	88.87	gold quality
right lobe of liver	UBERON:0001114	88.71	gold quality
rectum	UBERON:0001052	88.34	gold quality
monocyte	CL:0000576	88.14	gold quality
bone marrow	UBERON:0002371	88.05	gold quality
small intestine Peyer’s patch	UBERON:0003454	87.89	gold quality
small intestine	UBERON:0002108	87.61	gold quality
stomach	UBERON:0000945	87.44	gold quality
fundus of stomach	UBERON:0001160	87.34	gold quality
metanephros cortex	UBERON:0010533	87.21	gold quality
transverse colon	UBERON:0001157	87.17	gold quality
right adrenal gland cortex	UBERON:0035827	86.85	gold quality
pituitary gland	UBERON:0000007	86.83	gold quality
body of pancreas	UBERON:0001150	86.67	gold quality
right ovary	UBERON:0002118	86.61	gold quality
body of stomach	UBERON:0001161	86.60	gold quality
left ovary	UBERON:0002119	86.59	gold quality
skin of abdomen	UBERON:0001416	86.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• We showed that miR-8075 that was downregulated in cervical cancer tissues repressed cervical cancer cell proliferation, migration, and invasion. Furthermore, we validated that upregulation of TPX2 by hsa_circRNA_101996-mediated inhibition of miR-8075 contributed to cervical cancer proliferation, migration, and invasion (PMID:30633364)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.