MIR8076

Summary

MIR8076 (microRNA 8076, HGNC:49997) is a microRNA gene on chromosome 3q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466253 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49997
Approved symbol	MIR8076
Name	microRNA 8076
Location	3q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8076
Ensembl gene	ENSG00000275670
Ensembl biotype	miRNA
Entrez	102466253
RNAcentral	URS0000759E84 — ncRNA, 83 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611401

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611401 — 1 exons

Exon	Start	End
ENSE00003716302	113432118	113432200

Expression profiles

Bgee: expression breadth broad, 61 present calls, max score 77.36.

Top tissues by expression

61 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	77.36	gold quality
liver	UBERON:0002107	76.14	gold quality
endometrium	UBERON:0001295	75.56	gold quality
adrenal tissue	UBERON:0018303	74.89	gold quality
lung	UBERON:0002048	72.87	gold quality
calcaneal tendon	UBERON:0003701	72.27	gold quality
kidney	UBERON:0002113	72.09	gold quality
heart left ventricle	UBERON:0002084	71.98	gold quality
adult mammalian kidney	UBERON:0000082	71.18	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.05	gold quality
intestine	UBERON:0000160	68.57	gold quality
stomach	UBERON:0000945	68.35	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.67	gold quality
body of pancreas	UBERON:0001150	67.22	gold quality
corpus callosum	UBERON:0002336	66.67	gold quality
heart	UBERON:0000948	66.36	gold quality
putamen	UBERON:0001874	66.27	gold quality
body of stomach	UBERON:0001161	66.14	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.80	gold quality
descending thoracic aorta	UBERON:0002345	65.38	gold quality
right adrenal gland	UBERON:0001233	64.83	gold quality
right uterine tube	UBERON:0001302	64.78	gold quality
minor salivary gland	UBERON:0001830	64.76	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.54	gold quality
skin of abdomen	UBERON:0001416	64.53	gold quality
tibial artery	UBERON:0007610	64.50	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.32	gold quality
Ammon’s horn	UBERON:0001954	64.05	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.91	gold quality
colon	UBERON:0001155	63.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.