MIR8077

Summary

MIR8077 (microRNA 8077, HGNC:50266) is a microRNA gene on chromosome 19q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465875 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50266
Approved symbol	MIR8077
Name	microRNA 8077
Location	19q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8077
Ensembl gene	ENSG00000277533
Ensembl biotype	miRNA
Entrez	102465875
RNAcentral	URS000075A1A7 — miRNA, 75 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618566

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618566 — 1 exons

Exon	Start	End
ENSE00003727824	42351131	42351205

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 68.60.

Top tissues by expression

6 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left adrenal gland	UBERON:0001234	68.60	gold quality
anterior cingulate cortex	UBERON:0009835	66.92	gold quality
right frontal lobe	UBERON:0002810	62.50	gold quality
cerebellar hemisphere	UBERON:0002245	62.22	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.59	gold quality
right hemisphere of cerebellum	UBERON:0014890	60.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.06

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.