MIR8078

Summary

MIR8078 (microRNA 8078, HGNC:50102) is a microRNA gene on chromosome 18p11.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466878 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50102
Approved symbol	MIR8078
Name	microRNA 8078
Location	18p11.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8078
Ensembl gene	ENSG00000277521
Ensembl biotype	miRNA
Entrez	102466878
RNAcentral	URS000075DC45 — miRNA, 84 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619811

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619811 — 1 exons

Exon	Start	End
ENSE00003749996	112256	112339

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 97.90.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.90	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.82	gold quality
monocyte	CL:0000576	82.57	gold quality
adrenal tissue	UBERON:0018303	79.51	gold quality
muscle of leg	UBERON:0001383	74.23	gold quality
blood	UBERON:0000178	73.95	gold quality
kidney	UBERON:0002113	73.79	gold quality
gastrocnemius	UBERON:0001388	73.08	gold quality
right atrium auricular region	UBERON:0006631	70.19	gold quality
body of pancreas	UBERON:0001150	69.83	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	69.65	gold quality
body of stomach	UBERON:0001161	69.57	gold quality
heart left ventricle	UBERON:0002084	69.32	gold quality
right adrenal gland	UBERON:0001233	68.06	gold quality
left adrenal gland	UBERON:0001234	67.88	gold quality
ascending aorta	UBERON:0001496	67.83	gold quality
thoracic aorta	UBERON:0001515	67.76	gold quality
prefrontal cortex	UBERON:0000451	67.72	gold quality
endometrium	UBERON:0001295	67.68	gold quality
stomach	UBERON:0000945	67.63	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.29	gold quality
left adrenal gland cortex	UBERON:0035825	66.96	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.75	gold quality
lung	UBERON:0002048	66.58	gold quality
tibial artery	UBERON:0007610	66.03	gold quality
intestine	UBERON:0000160	65.72	gold quality
apex of heart	UBERON:0002098	65.65	gold quality
colon	UBERON:0001155	65.30	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.12	gold quality
transverse colon	UBERON:0001157	65.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.